Protein Alignment CG12605 and ZFY

DIOPT Version :10

• Sequence 1: NP_647845.2
• Gene: CG12605 / 38468
• FlyBaseID: FBgn0035481
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_003402.2
• Gene: ZFY / 7544
• HGNCID: 12870
• Length: 801
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 115/524 - (21%)
• Similarity: 176/524 - (33%)
• Gaps: 158/524 - (30%)

  Fly   107 IDLDDEDGEEQEDQLCEHLEWSAAQSLVQMNSSKQEKQRRAGTTGSPATVAAPVSASVS----LR 167
            :|..|.|....||.|...|:          ::.|.|.....|.|....:...|.....:    ::
Human   194 VDQQDNDKASCEDYLMISLD----------DAGKIEHDGSTGVTIDAESEMDPCKVDSTCPEVIK 248

  Fly   168 RPVGRA-PAED---GKV-IFYAPPASASGSPRQPEPVALKRERER-------DKEREREKERERD 220
            ..:.:| |.||   |.| |..:.|.:..|.....:..:::..||:       |.::|
Human   249 VYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQQE-------- 305

  Fly   221 RMREQQLVAATAAASIYRGRSVEETEAAHDLLSLSQSLPPLIPPCVVTIMKQEQEQLRSPEIQEI 285
               ::.|..|..|..:|....|.|.:||             :......:.:|:.::........|
Human   306 ---DEDLNVAEIADEVYMEVIVGEEDAA-------------VAAAAAAVHEQQIDEDEMKTFVPI 354

  Fly   286 SNSASSRSPQSTIRFIGSSSYDLMGGSSEGANNCSPLTPPNSDHSSDVDIDMSSSSESGLQQWGK 350
            :.:|:                  .|.:|:|..|      .|...|:.:.||.|    :||.:..|
Human   355 AWAAA------------------YGNNSDGIEN------RNGTASALLHIDES----AGLGRLAK 391

  Fly   351 PNPQQNQQRASALKMCLNMLDGRTKASKAAAVTKQDRQEPMQPRPKSAQSNASSGGGPPSEP-PE 414
            ..|::.:                                    ||.|.|...:...||...| ..
Human   392 QKPKKKR------------------------------------RPDSRQYQTAIIIGPDGHPLTV 420

  Fly   415 NPAASLGHSSSGNG----------ENYAKRKRGC-----------------------------YK 440
            .|....|......|          |:.||:|..|                             .:
Human   421 YPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTNKKISLHNHLESHKLTSKAEKAIE 485

  Fly   441 CCECGKQYATSSNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPALAMHLL---THKLSHSCDICG 502
            |.||||.::.:..|..||..|:...:....||..|.........|..|||   :....|.|..||
Human   486 CDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECG 550

  Fly   503 KLFSRPWLLQGHLRSHTGEKPYACVHCGKAFADRSNLRAHMQT-HSGDKNFKCHRCNKTFALKSY 566
            |.|..|..|:.|:|.|||||||.|.:|....||.|||:.|::| ||.:..|||..|..||:....
Human   551 KGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHIKTKHSKEMPFKCDICLLTFSDTKE 615

  Fly   567 LNKH 570
            :.:|
Human   616 VQQH 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_647845.2	COG5048	283..>561	CDD:227381	78/321 (24%)
		zf-C2H2	439..461	CDD:395048	8/21 (38%)
		C2H2 Zn finger	441..461	CDD:275370	8/19 (42%)
		C2H2 Zn finger	472..492	CDD:275368	6/22 (27%)
		zf-C2H2	496..518	CDD:395048	10/21 (48%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	511..534	CDD:463886	12/22 (55%)
		zf-C2H2	524..546	CDD:395048	10/22 (45%)
		C2H2 Zn finger	526..546	CDD:275368	9/20 (45%)
		zf-H2C2_2	538..562	CDD:463886	11/24 (46%)
		C2H2 Zn finger	554..571	CDD:275368	5/17 (29%)
ZFY	NP_003402.2	Zfx_Zfy_act	71..406	CDD:461400	53/309 (17%)
		COG5048	<417..592	CDD:227381	50/174 (29%)
		C2H2 Zn finger	423..443	CDD:275368	2/19 (11%)
		C2H2 Zn finger	454..478	CDD:275368	1/23 (4%)
		C2H2 Zn finger	486..506	CDD:275368	8/19 (42%)
		COG5048	539..>676	CDD:227381	35/81 (43%)
		C2H2 Zn finger	546..566	CDD:275368	9/19 (47%)
		zf-H2C2_2	558..582	CDD:463886	12/23 (52%)
		C2H2 Zn finger	574..593	CDD:275368	8/18 (44%)
		C2H2 Zn finger	603..652	CDD:275368	5/17 (29%)
		C2H2 Zn finger	660..680	CDD:275368
		zf-C2H2	715..737	CDD:395048
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..753	CDD:463886
		C2H2 Zn finger	745..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368