DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12605 and SNAI1

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_005976.2	Gene:	SNAI1 / 6615	HGNCID:	11128	Length:	264	Species:	Homo sapiens

Alignment Length:	192	Identity:	86/192 - (44%)
Similarity:	111/192 - (57%)	Gaps:	18/192 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 MQPRPKSAQ----SNASSGGG--PPSEPPENPAASLGHS-SSGNGENYAKRKRGCYKCCECGKQY 448
            :|..|:.|:    |:..||.|  |||.|...|::....| ||...|.||    ......:..||.
Human    79 LQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYA----AFPGLGQVPKQL 139

  Fly   449 ATSSNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPALAMHLLTHKLSHSCDICGKLFSRPWLLQG 513
            |..|..       :.|.::.|..|..|.|.|:|:.||.||:.:|.|...|..|||.|||||||||
Human   140 AQLSEA-------KDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQG 197

  Fly   514 HLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLESAC 575
            |:|:||||||::|.||.:|||||||||||:||||..|.::|..|.:||:..|.|:||.||.|
Human   198 HVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGC 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	4/21 (19%)
		C2H2 Zn finger	441..461	CDD:275370	4/19 (21%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		COG5048	492..>570	CDD:227381	48/77 (62%)
		zf-C2H2	496..518	CDD:278523	15/21 (71%)
		C2H2 Zn finger	498..518	CDD:275368	15/19 (79%)
		zf-H2C2_2	511..534	CDD:290200	15/22 (68%)
		zf-C2H2	524..546	CDD:278523	15/21 (71%)
		C2H2 Zn finger	526..546	CDD:275368	15/19 (79%)
		zf-H2C2_2	538..562	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..571	CDD:275368	7/16 (44%)
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SNAG domain. /evidence=ECO:0000305\|PubMed:20389281, ECO:0000305\|PubMed:21300290	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:23721412	2..7
		LATS2 binding	10..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..115		10/28 (36%)
		Destruction motif	95..100		2/4 (50%)
		Required for FBXL14-triggered degradation	120..151		9/41 (22%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269\|PubMed:21577210, ECO:0000269\|PubMed:22128911	151..264		63/109 (58%)
		C2H2 Zn finger	156..176	CDD:275368	9/19 (47%)
		C2H2 Zn finger	182..202	CDD:275368	15/19 (79%)
		zf-H2C2_2	195..218	CDD:404364	15/22 (68%)
		zf-C2H2	208..230	CDD:395048	15/21 (71%)
		C2H2 Zn finger	210..230	CDD:275368	15/19 (79%)
		C2H2 Zn finger	238..255	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810