Protein Alignment CG12605 and Plag1

DIOPT Version :10

• Sequence 1: NP_647845.2
• Gene: CG12605 / 38468
• FlyBaseID: FBgn0035481
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_064353.2
• Gene: Plag1 / 56711
• MGIID: 1891916
• Length: 499
• Species: Mus musculus
• Alignment Length: 268
• Identity: 52/268 - (19%)
• Similarity: 104/268 - (38%)
• Gaps: 95/268 - (35%)

  Fly    72 EWGHQFLSAHVDLSEMDALEREIEALKPKVRDMLISSESSKKKILFLY---------LLVSLGLA 127
            :|.|   ..|:..:..|.:|         :::|:..|..:|...|:.|         :.||...|
Mouse   153 DWLH---GRHLGCAVPDCVE---------LQEMICESCMNKTPFLWNYAAQIAVSPIIKVSPCKA 205

  Fly   128 YHFEDEIKESLEDGLQKIEEMMASED-----DLRFKGDNGKFKECLAKDAKGILSLYEAAHMGTT 187
               |:::|..:|.  ::.|:|:.:|:     |.:..|.:| .|..|..:::|     .:.| |..
Mouse   206 ---EEDVKVEVEK--EEEEKMVKNENTKSAVDEKMNGTSG-CKRKLQDESEG-----SSGH-GLC 258

  Fly   188 TDYILDEALSFTLTYMESLAASGTCKINLSRRIRKALDQPQH--------KNMEIIVAMKYIQFY 244
            :...|.|           :.|||     :||:.:.|:..|..        .:.:::.|...:.|.
Mouse   259 SGCRLRE-----------MKASG-----ISRKQQGAVFWPSAWRTKLCSCPDCKVLYADAGLCFL 307

  Fly   245 EEEEDCDKTLLKF-----------------------AKLNFKFLQLHYLQELKILSKWYKDQDFK 286
            .:|.|   |:|.:                       :.||    .|:.:|:|:|:.::   .|.|
Mouse   308 TDEAD---TVLAYENKGKSTEQAEQAGGAGGRDPLMSALN----NLNRVQQLEIIHEY---NDMK 362

  Fly   287 SKLPPYFR 294
            ::|..|.:
Mouse   363 TELKDYLQ 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_647845.2	COG5048	283..>561	CDD:227381	4/12 (33%)
		zf-C2H2	439..461	CDD:395048
		C2H2 Zn finger	441..461	CDD:275370
		C2H2 Zn finger	472..492	CDD:275368
		zf-C2H2	496..518	CDD:395048
		C2H2 Zn finger	498..518	CDD:275368
		zf-H2C2_2	511..534	CDD:463886
		zf-C2H2	524..546	CDD:395048
		C2H2 Zn finger	526..546	CDD:275368
		zf-H2C2_2	538..562	CDD:463886
		C2H2 Zn finger	554..571	CDD:275368
Plag1	NP_064353.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		Interaction with KPNA2. /evidence=ECO:0000250	2..84
		Nuclear localization signal. /evidence=ECO:0000250	22..25
		C2H2 Zn finger	36..56	CDD:275368
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		22/106 (21%)
		SFP1	<58..139	CDD:227516
		C2H2 Zn finger	64..86	CDD:275368
		zf-H2C2_2	79..101	CDD:463886
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	123..143	CDD:275368
		C2H2 Zn finger	152..172	CDD:275368	5/30 (17%)
		C2H2 Zn finger	187..207	CDD:275368	4/22 (18%)
		C2H2 Zn finger	215..233	CDD:275368	3/19 (16%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		29/160 (18%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		29/160 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..400		2/6 (33%)
		Massively activates transcription. /evidence=ECO:0000250	384..499