Protein Alignment CG12605 and PLAG1

DIOPT Version :10

• Sequence 1: NP_647845.2
• Gene: CG12605 / 38468
• FlyBaseID: FBgn0035481
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_002646.2
• Gene: PLAG1 / 5324
• HGNCID: 9045
• Length: 500
• Species: Homo sapiens
• Alignment Length: 194
• Identity: 57/194 - (29%)
• Similarity: 78/194 - (40%)
• Gaps: 51/194 - (26%)

  Fly   422 HSSSGNGENYAKRKRGCYKCC--ECGKQYATSSNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPA 484
            ||.|..||.       .|||.  :|.|.:.:...|.||..||   ..:...|||.|.|.:.....
Human    52 HSYSHTGER-------PYKCIQQDCTKAFVSKYKLQRHMATH---SPEKTHKCNYCEKMFHRKDH 106

  Fly   485 LAMHLLTH---KLSHSCDICGK-----------------------------LFSRPWLLQGHLRS 517
            |..||.||   |.:..|:.|||                             .|....:|..||:|
Human   107 LKNHLHTHDPNKETFKCEECGKNYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKS 171

  Fly   518 HTG-------EKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLESA 574
            |.|       ||.:.|.||.:.|..|.::|.||..|:|.|:|.|..|.:.|..|.:|.:|::.:
Human   172 HAGKSSGGVKEKKHQCEHCDRRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKS 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_647845.2	COG5048	283..>561	CDD:227381	53/179 (30%)
		zf-C2H2	439..461	CDD:395048	8/23 (35%)
		C2H2 Zn finger	441..461	CDD:275370	6/21 (29%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		zf-C2H2	496..518	CDD:395048	8/50 (16%)
		C2H2 Zn finger	498..518	CDD:275368	8/48 (17%)
		zf-H2C2_2	511..534	CDD:463886	11/29 (38%)
		zf-C2H2	524..546	CDD:395048	8/21 (38%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	538..562	CDD:463886	9/23 (39%)
		C2H2 Zn finger	554..571	CDD:275368	5/16 (31%)
PLAG1	NP_002646.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Interaction with KPNA2. /evidence=ECO:0000269|PubMed:11882654	2..84		13/38 (34%)
		Nuclear localization signal	22..25
		C2H2 Zn finger	36..56	CDD:275368	2/3 (67%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		57/194 (29%)
		SFP1	<58..139	CDD:227516	27/90 (30%)
		C2H2 Zn finger	64..86	CDD:275368	6/21 (29%)
		zf-H2C2_2	79..101	CDD:463886	10/24 (42%)
		C2H2 Zn finger	94..114	CDD:275368	7/19 (37%)
		C2H2 Zn finger	123..143	CDD:275368	4/19 (21%)
		C2H2 Zn finger	152..172	CDD:275368	4/19 (21%)
		C2H2 Zn finger	187..207	CDD:275368	8/19 (42%)
		C2H2 Zn finger	215..233	CDD:275368	6/17 (35%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500