DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12605 and Zkscan1

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001020931.1	Gene:	Zkscan1 / 498160	RGDID:	1560616	Length:	562	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	131/527 - (24%)
Similarity:	186/527 - (35%)	Gaps:	139/527 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 ATVAAPVSASVSLRRPVGRAPAEDGKVIFYAPPASASGSPRQPEPVALKRE------------RE 206
            ||..:|.:|.......:.:...||.:...:...||...:| .|:|...::.            ||
  Rat     9 ATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDASLQETP-PPDPEVFRQRFRRFCYQNTFGPRE 72

  Fly   207 ---RDKEREREKERERDRMREQ--QLVAATAAASI-----------YRGRSVEETEAAHDLLSLS 255
               |.||...:..|.....:||  :|:......||           ||..|.||.....:.|.|.
  Rat    73 ALNRLKELCHQWLRPEVNTKEQILELLVLEQFLSILPKELQVWLQEYRPDSGEEAVTLLEDLELD 137

  Fly   256 QSLPPLIPPCVVTIMKQEQEQLRSPE-----------IQEISNSASSRSPQSTIRFIGSSSYDLM 309
            .|            .:|...|:..||           :||.|:.....:.||..:.
  Rat   138 LS------------GQQVPGQVHGPEMLARGVVPLDPVQESSSFDHHEAAQSHFKH--------- 181

  Fly   310 GGSSEGANNCSPLTPP-----------------------NSDHSSDVDI-DMSSSSESGLQQWGK 350
              ||......||...|                       .:|..:.|.| ||:.|..  |::||.
  Rat   182 --SSRKPRLLSPRALPATHVPAPQHEGNPRDQAMASALLTADSQAMVKIEDMAVSLI--LEEWGC 242

  Fly   351 PNPQQNQQRASALKMCLNML--------DGRTKASKAAAV------------------TKQDRQ- 388
            .|..:......:.:|.|..:        :|....|||...                  .|:::|
  Rat   243 QNLARRNLNRDSRQMNLGTVFSQGSENRNGSESTSKAEVKGDSTSHGEIAGRFQKEFGEKREQQG 307

  Fly   389 ---EPMQPRPKSAQSNASSGGGPPSEPPENPAA----------SLGHSSS-----GNGENYAKRK 435
               |..|..|:..........|||:...:.|..          .||.|.|     .|........
  Rat   308 RVIERQQKNPEEKTGKEKKAPGPPTAKEKKPTTGERGPREKGKGLGRSFSLSANFNNTPEEIPSG 372

  Fly   436 RGCYKCCECGKQYATSSNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPALAMHLLTH--KLSHSC 498
            ...::|.||||.:..||:|.|||..|   ..:...:||.||||:.....|.:|...|  :..|.|
  Rat   373 AKTHRCDECGKCFTRSSSLIRHKIIH---TGEKPYECNECGKAFSLNSNLVLHQRIHTGEKPHEC 434

  Fly   499 DICGKLFSRPWLLQGHLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFAL 563
            :.|||.||....|..|.|.|:|||||.|..|||||:..|:|..|.:.|:|:|.::|..|.|.|..
  Rat   435 NECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNR 499

  Fly   564 KSYLNKH 570
            .|||..|
  Rat   500 NSYLILH 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	11/21 (52%)
		C2H2 Zn finger	441..461	CDD:275370	11/19 (58%)
		C2H2 Zn finger	472..492	CDD:275368	8/19 (42%)
		COG5048	492..>570	CDD:227381	36/79 (46%)
		zf-C2H2	496..518	CDD:278523	10/21 (48%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	511..534	CDD:290200	14/22 (64%)
		zf-C2H2	524..546	CDD:278523	10/21 (48%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		zf-H2C2_2	538..562	CDD:290200	8/23 (35%)
		C2H2 Zn finger	554..571	CDD:275368	8/17 (47%)
Zkscan1	NP_001020931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..50		5/19 (26%)
		SCAN	52..162	CDD:128708	24/121 (20%)
		SCAN	52..129	CDD:280241	17/76 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..187		7/33 (21%)
		KRAB	226..264	CDD:279668	11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..372		18/110 (16%)
		C2H2 Zn finger	353..370	CDD:275368	4/16 (25%)
		COG5048	<355..536	CDD:227381	60/155 (39%)
		zf-C2H2	376..398	CDD:278523	11/21 (52%)
		C2H2 Zn finger	378..398	CDD:275368	11/19 (58%)
		zf-H2C2_2	390..414	CDD:290200	11/26 (42%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		zf-H2C2_2	418..443	CDD:290200	9/24 (38%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		zf-H2C2_2	446..471	CDD:290200	15/24 (63%)
		C2H2 Zn finger	462..482	CDD:275368	9/19 (47%)
		zf-H2C2_2	474..499	CDD:290200	9/24 (38%)
		C2H2 Zn finger	490..510	CDD:275368	8/17 (47%)
		zf-H2C2_2	502..527	CDD:290200	3/5 (60%)
		C2H2 Zn finger	518..538	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4772
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050