DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12605 and CG4854

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	73/312 - (23%)
Similarity:	117/312 - (37%)	Gaps:	93/312 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 VTIMKQEQEQLRSPEIQEISNSASSRSPQSTIRFIGSSSYDLMGGSSEGANNCSPLTPPNSDHSS 331
            :.|:..|||..:..|.:::|.:.::.| .|.:.:....|||:...|||.. .||      :|...
  Fly    88 IEIVHDEQETKKKTESRDLSKNEATGS-DSELEYEYLDSYDVTLESSEDV-ACS------ADELV 144

  Fly   332 DVDIDMSSSSESGLQQWGKPNPQQNQQRASALKMCLNMLDGRTKASKAAAVTKQDRQEPMQPRPK 396
            .::..:|:..||...                                            :.|:|.
  Fly   145 SIEPAISAPEESVYS--------------------------------------------LSPKPV 165

  Fly   397 SAQSNASSGGGPPSEPPENPAASLGHSSSGNGENYAKRKRGCYKCCECGKQYATSSNLSRHKQTH 461
            :.:...|                 |.::|             :.|..|...|:....|:.|.:.|
  Fly   166 TFEDEDS-----------------GQAAS-------------FTCNICNNVYSERVKLTNHMKVH 200

  Fly   462 RSLDSQSAKK---CNTCGKAYVSMPALAMHLLTH--KLSHSCDICGKLFSRPWLLQGHLRSHTGE 521
                  ||||   |..|.|.:...|.||.|:.||  ...:.||.|...|:.|.....|.|.||.|
  Fly   201 ------SAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIHTNE 259

  Fly   522 KPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLES 573
            :||.|..|.::|...:.||.|::||:|::.|.|..|.|:|:...:.|.|.:|
  Fly   260 RPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEKS 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	5/21 (24%)
		C2H2 Zn finger	441..461	CDD:275370	5/19 (26%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		COG5048	492..>570	CDD:227381	28/79 (35%)
		zf-C2H2	496..518	CDD:278523	7/21 (33%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	511..534	CDD:290200	9/22 (41%)
		zf-C2H2	524..546	CDD:278523	7/21 (33%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	538..562	CDD:290200	10/23 (43%)
		C2H2 Zn finger	554..571	CDD:275368	5/16 (31%)
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	193..217	CDD:290200	10/29 (34%)
		COG5048	201..>258	CDD:227381	21/56 (38%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..244	CDD:290200	8/22 (36%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	251..273	CDD:290200	10/21 (48%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..301	CDD:290200	11/23 (48%)
		C2H2 Zn finger	292..312	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100