DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12605 and sna

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_476732.1	Gene:	sna / 34908	FlyBaseID:	FBgn0003448	Length:	390	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	132/417 - (31%)
Similarity:	185/417 - (44%)	Gaps:	107/417 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 QPEPVALKRERERDKEREREKERERDRM----REQQLVAATAAASIYRGRSVEETEAAHDLL--- 252
            ||:.::|||.|:.:.:..::.|.:||.:    :..:..:::::.|......||    |.|.|
  Fly    40 QPQDLSLKRGRDEETQDYQQPEPKRDYVLNLSKTPERNSSSSSNSCLLSPPVE----AQDYLPTE 100

  Fly   253 -----------SLSQSLPPLIPP----------C--VVTIMKQEQEQLRSPEIQEISNSASS-RS 293
                       ..:.:.|..|.|          |  :..:....|     |.:....:.||| .|
  Fly   101 IHMRGLTAGTTGYTTATPTTINPFQSAFVMAAGCNPISALWSSYQ-----PHLAAFPSPASSMAS 160

  Fly   294 PQSTIRFIGSSSYDLMGGSSEGANNCSPLTPPNSDHSSDVDIDMSSSSESGLQQWGKPNPQQNQQ 358
            |||..      ||..|             |||:|..|     |:.:.||          |:....
  Fly   161 PQSVY------SYQQM-------------TPPSSPGS-----DLETGSE----------PEDLSV 191

  Fly   359 RAS-ALKMCLNMLDGRTKASKAAAVTKQDRQEPMQPRPKSAQSNASSGGGPPSEPPENPAASLGH 422
            |.. .|....::.|....:|..|:|                    ||..|....|      ::..
  Fly   192 RNDIPLPALFHLFDEAKSSSSGASV--------------------SSSSGYSYTP------AMSA 230

  Fly   423 SSSGNGENYAKRKRGCYKCCECGKQYATSSNLSRHKQTH-RSLDSQSAKK---CNTCGKAYVSMP 483
            ||:....|:||..|  :||.||.|.|:||..||:|:|.| .:.:....||   |..|||.|.::.
  Fly   231 SSASVAANHAKNYR--FKCDECQKMYSTSMGLSKHRQFHCPAAECNQEKKTHSCEECGKLYTTIG 293

  Fly   484 ALAMHLLTHKLSHSCDICGKLFSRPWLLQGHLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSG 548
            ||.||:.||.|...|.||||.||||||||||:|:||||||:.|..|.::||||||||||.|||..
  Fly   294 ALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFQCPDCPRSFADRSNLRAHQQTHVD 358

  Fly   549 DKNFKCHRCNKTFALKSYLNKHLESAC 575
            .|.:.|..|:|:|:..|.||||..|.|
  Fly   359 VKKYACQVCHKSFSRMSLLNKHSSSNC 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	12/21 (57%)
		C2H2 Zn finger	441..461	CDD:275370	11/19 (58%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		COG5048	492..>570	CDD:227381	47/77 (61%)
		zf-C2H2	496..518	CDD:278523	16/21 (76%)
		C2H2 Zn finger	498..518	CDD:275368	16/19 (84%)
		zf-H2C2_2	511..534	CDD:290200	13/22 (59%)
		zf-C2H2	524..546	CDD:278523	13/21 (62%)
		C2H2 Zn finger	526..546	CDD:275368	13/19 (68%)
		zf-H2C2_2	538..562	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..571	CDD:275368	8/16 (50%)
sna	NP_476732.1	C2H2 Zn finger	308..328	CDD:275368	16/19 (84%)
		zf-H2C2_2	321..344	CDD:290200	13/22 (59%)
		zf-C2H2	334..356	CDD:278523	13/21 (62%)
		C2H2 Zn finger	336..356	CDD:275368	13/19 (68%)
		zf-H2C2_2	348..373	CDD:290200	13/24 (54%)
		C2H2 Zn finger	364..380	CDD:275368	7/15 (47%)
		C2H2 Zn finger	247..267	CDD:275368	11/19 (58%)
		C2H2 Zn finger	282..302	CDD:275368	9/19 (47%)
		zf-C2H2	306..328	CDD:278523	16/21 (76%)
		COG5048	307..>356	CDD:227381	35/48 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D37106at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750