DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12605 and SNAI3

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_840101.1	Gene:	SNAI3 / 333929	HGNCID:	18411	Length:	292	Species:	Homo sapiens

Alignment Length:	284	Identity:	104/284 - (36%)
Similarity:	140/284 - (49%)	Gaps:	36/284 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 DLMGGSSEGANNCSPLTPPNSDHSSDVDIDMSSSSESGLQQWGKPN----------PQQNQQRAS 361
            ::.|..|.......||.|.:.:..| |..|:.       |.|.:.:          |:..:...:
Human    26 EINGACSACGGLVVPLLPRDKEAPS-VPGDLP-------QPWDRSSAVACISLPLLPRIEEALGA 82

  Fly   362 ALKMCLNMLDGRTKASKAAAVTKQDRQEPMQPRPKSAQSNASSGGGPPSEPPENPAASLGHSSSG 426
            :....|.:.:...:||:||.|..:|....:...|....             |...:.:||....|
Human    83 SGLDALEVSEVDPRASRAAIVPLKDSLNHLNLPPLLVL-------------PTRWSPTLGPDRHG 134

  Fly   427 NGENYAKRKR-----GCYKCCECGKQYATSSNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPALA 486
            ..|.....:|     |.::|..|.|.|.|.:.|:||:|.|..|.......|..|.|.|.|:.||.
Human   135 APEKLLGAERMPRAPGGFECFHCHKPYHTLAGLARHRQLHCHLQVGRVFTCKYCDKEYTSLGALK 199

  Fly   487 MHLLTHKLSHSCDICGKLFSRPWLLQGHLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKN 551
            ||:.||.|..:|.||||.||||||||||:|:|||||||||.||.:|||||||||||:||||..|.
Human   200 MHIRTHTLPCTCKICGKAFSRPWLLQGHVRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDAKK 264

  Fly   552 FKCHRCNKTFALKSYLNKHLESAC 575
            ::|.||.|||:..|.|.:|.||.|
Human   265 YRCRRCTKTFSRMSLLARHEESGC 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275370	9/19 (47%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		COG5048	492..>570	CDD:227381	53/77 (69%)
		zf-C2H2	496..518	CDD:278523	16/21 (76%)
		C2H2 Zn finger	498..518	CDD:275368	16/19 (84%)
		zf-H2C2_2	511..534	CDD:290200	17/22 (77%)
		zf-C2H2	524..546	CDD:278523	17/21 (81%)
		C2H2 Zn finger	526..546	CDD:275368	15/19 (79%)
		zf-H2C2_2	538..562	CDD:290200	15/23 (65%)
		C2H2 Zn finger	554..571	CDD:275368	8/16 (50%)
SNAI3	NP_840101.1	SNAG domain. /evidence=ECO:0000250	1..20
		C2H2 Zn finger	154..174	CDD:275370	9/19 (47%)
		C2H2 Zn finger	185..205	CDD:275368	9/19 (47%)
		COG5048	<206..>278	CDD:227381	50/71 (70%)
		C2H2 Zn finger	211..231	CDD:275368	16/19 (84%)
		C2H2 Zn finger	239..259	CDD:275368	15/19 (79%)
		C2H2 Zn finger	267..283	CDD:275368	8/15 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810