DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12605 and ZBTB48

DIOPT Version :9

Sequence 1:NP_001261387.1 Gene:CG12605 / 38468 FlyBaseID:FBgn0035481 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_001265576.1 Gene:ZBTB48 / 3104 HGNCID:4930 Length:688 Species:Homo sapiens


Alignment Length:455 Identity:106/455 - (23%)
Similarity:161/455 - (35%) Gaps:142/455 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 REQQLVAATAAASIYRGRSVEETEAAHDLLSLSQSLPP-------------LIPPCVVTIMK--- 271
            |:|.|:||         |.:...||    :.|.||..|             |.||....:..   
Human    92 RDQVLLAA---------RELRVPEA----VELCQSFKPKTSVGQAAGGQSGLGPPASQNVNSHVK 143

  Fly   272 -----QEQEQLRS----PEIQEISNSASSRSPQ--STIRFIGSSSYDLMGGSSEGANNCSPLTPP 325
                 :|:|..|:    |..||...|.|.:.||  |..:..|.||  |.|...:....|    |.
Human   144 EPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSPAQSEGPSS--LCGKLKQALKPC----PL 202

  Fly   326 NSDHSSDVDIDMSSSSESGLQQWGKPNPQQNQQRASALKMCLNMLDGRTKASKAAAVTKQDRQEP 390
            ......|..:........|.|..|..|..:      .:....:..||...:...|.:|:  |:..
Human   203 EDKKPEDCKVPPRPLEAEGAQLQGGSNEWE------VVVQVEDDGDGDYMSEPEAVLTR--RKSN 259

  Fly   391 MQPRPKSAQSNASSGGGPPSEPPENPAASL-------------------GHSSSGNGENYAKRKR 436
            :..:|.:|:. |.|.|...:||.||...:.                   .|:....||.      
Human   260 VIRKPCAAEP-ALSAGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNRKHTGEK------ 317

  Fly   437 GCYKCCECGKQYATSSNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPALAMHLLTH--------- 492
             .::|.:|||.|....||..|:..:....|:....|:.|.:.:.....|.:|:::|         
Human   318 -PFECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCS 381

  Fly   493 -----------------KL-----SHSCDICGKLF-SRPWL------------------------ 510
                             ||     .|:|..|.|.| ||..|                        
Human   382 SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRAS 446

  Fly   511 ----LQGHLRS-HTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKH 570
                ||.|::: |..|:|:.|..|..||..::||..|::||:|:|.|:||.|.|||..::.|:||
Human   447 SRNGLQMHIKAKHRNERPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKH 511

  Fly   571  570
            Human   512  511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12605NP_001261387.1 zf-C2H2 439..461 CDD:278523 8/21 (38%)
C2H2 Zn finger 441..461 CDD:275370 8/19 (42%)
C2H2 Zn finger 472..492 CDD:275368 4/19 (21%)
COG5048 492..>570 CDD:227381 36/138 (26%)
zf-C2H2 496..518 CDD:278523 11/51 (22%)
C2H2 Zn finger 498..518 CDD:275368 10/49 (20%)
zf-H2C2_2 511..534 CDD:290200 9/23 (39%)
zf-C2H2 524..546 CDD:278523 7/21 (33%)
C2H2 Zn finger 526..546 CDD:275368 7/19 (37%)
zf-H2C2_2 538..562 CDD:290200 13/23 (57%)
C2H2 Zn finger 554..571 CDD:275368 9/17 (53%)
ZBTB48NP_001265576.1 BTB 16..119 CDD:306997 12/39 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..140 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..192 12/32 (38%)
C2H2 Zn finger 293..313 CDD:275368 1/19 (5%)
zf-H2C2_2 305..328 CDD:316026 7/29 (24%)
C2H2 Zn finger 321..372 CDD:275368 13/50 (26%)
SFP1 <374..459 CDD:227516 13/84 (15%)
C2H2 Zn finger 380..401 CDD:275368 1/20 (5%)
C2H2 Zn finger 409..425 CDD:275370 7/15 (47%)
C2H2 Zn finger 438..459 CDD:275368 3/20 (15%)
COG5048 <464..612 CDD:227381 22/48 (46%)
C2H2 Zn finger 467..487 CDD:275368 7/19 (37%)
C2H2 Zn finger 495..515 CDD:275368 9/17 (53%)
C2H2 Zn finger 523..540 CDD:275368
C2H2 Zn finger 555..572 CDD:275368
C2H2 Zn finger 580..600 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

Return to query results.
Submit another query.