Protein Alignment CG12605 and Plag1

DIOPT Version :10

• Sequence 1: NP_647845.2
• Gene: CG12605 / 38468
• FlyBaseID: FBgn0035481
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001008317.1
• Gene: Plag1 / 297804
• RGDID: 1305286
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 186
• Identity: 53/186 - (28%)
• Similarity: 79/186 - (42%)
• Gaps: 35/186 - (18%)

  Fly   422 HSSSGNGEN-YAKRKRGC----------------------YKCCECGKQYATSSNLSRHKQTHRS 463
            ||.|..||. |....:.|                      :||..|.|.:....:|..|..||.
  Rat    52 HSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHD- 115

  Fly   464 LDSQSAKKCNTCGKAYVSMPALAMHLLTHKLSH---SCDICGKLFSRPWLLQGHLRSHTG----- 520
             .::...||..|||:|.:......||..|..:.   :|.:|.:.|....:|..||:||.|
  Rat   116 -PNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGG 179

  Fly   521 --EKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLESA 574
              ||.:.|.||.:.|..|.::|.||..|:|.|:|.|..|.:.|..|.:|.:|::.:
  Rat   180 VKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKS 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_647845.2	COG5048	283..>561	CDD:227381	49/171 (29%)
		zf-C2H2	439..461	CDD:395048	6/21 (29%)
		C2H2 Zn finger	441..461	CDD:275370	5/19 (26%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		zf-C2H2	496..518	CDD:395048	6/24 (25%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	511..534	CDD:463886	11/29 (38%)
		zf-C2H2	524..546	CDD:395048	8/21 (38%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	538..562	CDD:463886	9/23 (39%)
		C2H2 Zn finger	554..571	CDD:275368	5/16 (31%)
Plag1	NP_001008317.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		7/31 (23%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25
		C2H2 Zn finger	36..56	CDD:275368	2/3 (67%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		53/186 (28%)
		SFP1	<58..139	CDD:227516	18/82 (22%)
		C2H2 Zn finger	64..86	CDD:275368	1/21 (5%)
		zf-H2C2_2	79..101	CDD:463886	4/21 (19%)
		C2H2 Zn finger	94..114	CDD:275368	5/19 (26%)
		C2H2 Zn finger	123..143	CDD:275368	7/19 (37%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		C2H2 Zn finger	187..207	CDD:275368	8/19 (42%)
		C2H2 Zn finger	215..233	CDD:275368	6/17 (35%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..400
		Massively activates transcription. /evidence=ECO:0000250	384..499