DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12605 and Snai1

DIOPT Version :9

Sequence 1:NP_001261387.1 Gene:CG12605 / 38468 FlyBaseID:FBgn0035481 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_035557.1 Gene:Snai1 / 20613 MGIID:98330 Length:264 Species:Mus musculus


Alignment Length:194 Identity:81/194 - (41%)
Similarity:110/194 - (56%) Gaps:20/194 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 PMQPRPKSAQ--SNASSGGGPPSEPPENPAASLGHSSSGNGENYAKRKRGCYKCCECGKQYATSS 452
            |::..||:.:  |.:....|..|:||..|:.:....||.:..:..            .:.:....
Mouse    78 PLRESPKAVELTSLSDEDSGKSSQPPSPPSPAPSSFSSTSASSLE------------AEAFIAFP 130

  Fly   453 NLSR-HKQTHR---SLDSQSAK--KCNTCGKAYVSMPALAMHLLTHKLSHSCDICGKLFSRPWLL 511
            .|.: .||..|   :.|.||.|  .|..|.|.|:|:.||.||:.:|.|...|..|||.|||||||
Mouse   131 GLGQLPKQLARLSVAKDPQSRKIFNCKYCNKEYLSLGALKMHIRSHTLPCVCTTCGKAFSRPWLL 195

  Fly   512 QGHLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLESAC 575
            |||:|:||||||::|.||.:|||||||||||:||||..|.::|..|.:||:..|.|:||.||.|
Mouse   196 QGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHKHQESGC 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12605NP_001261387.1 zf-C2H2 439..461 CDD:278523 3/22 (14%)
C2H2 Zn finger 441..461 CDD:275370 3/20 (15%)
C2H2 Zn finger 472..492 CDD:275368 9/19 (47%)
COG5048 492..>570 CDD:227381 48/77 (62%)
zf-C2H2 496..518 CDD:278523 15/21 (71%)
C2H2 Zn finger 498..518 CDD:275368 15/19 (79%)
zf-H2C2_2 511..534 CDD:290200 15/22 (68%)
zf-C2H2 524..546 CDD:278523 15/21 (71%)
C2H2 Zn finger 526..546 CDD:275368 15/19 (79%)
zf-H2C2_2 538..562 CDD:290200 13/23 (57%)
C2H2 Zn finger 554..571 CDD:275368 7/16 (44%)
Snai1NP_035557.1 SNAG domain. /evidence=ECO:0000305 1..20
Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250|UniProtKB:O95863 2..7
LATS2 binding. /evidence=ECO:0000250 10..40
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..116 7/30 (23%)
Destruction motif 95..100 1/4 (25%)
Required for FBXL14-triggered degradation. /evidence=ECO:0000250 120..151 6/42 (14%)
Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000250 151..264 63/109 (58%)
C2H2 Zn finger 156..176 CDD:275368 9/19 (47%)
COG5048 <177..>253 CDD:227381 47/75 (63%)
C2H2 Zn finger 182..202 CDD:275368 15/19 (79%)
zf-H2C2_2 195..218 CDD:290200 15/22 (68%)
zf-C2H2 208..230 CDD:278523 15/21 (71%)
C2H2 Zn finger 210..230 CDD:275368 15/19 (79%)
C2H2 Zn finger 238..255 CDD:275368 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2462
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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