DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12605 and ZBTB7C

DIOPT Version :9

Sequence 1:NP_001261387.1 Gene:CG12605 / 38468 FlyBaseID:FBgn0035481 Length:619 Species:Drosophila melanogaster
Sequence 2:XP_016881094.1 Gene:ZBTB7C / 201501 HGNCID:31700 Length:668 Species:Homo sapiens


Alignment Length:614 Identity:125/614 - (20%)
Similarity:200/614 - (32%) Gaps:234/614 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 GKSPLKS------LAKRNSRSILKREIIDLDDEDG---------------EEQED-QLCEHL--- 125
            |:.|..|      |.|....::.:....|:|:..|               |::.| .||:.|   
Human    25 GQEPSPSWTANFLLCKMKGWALAENMANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVV 89

  Fly   126 ---EWSAAQSLVQMNSSKQEKQRRAGTTGS-----------PATVAA------------------ 158
               |:...:|::...|...:|...|||..|           |..:||                  
Human    90 QEQEYRTHRSVLAACSKYFKKLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAGNVK 154

  Fly   159 -------------PVSASVSLRRPVGRAPAEDGKVIFYAPPASASGSPRQPEPVALKRERERDKE 210
                         .|:..:.:..|.|....||.|               :.:......:.|.|:|
Human   155 HILNAARMLEIQCIVNVCLEIMEPGGDGGEEDDK---------------EDDDDDEDDDDEEDEE 204

  Fly   211 REREKERERDRMREQQLVAATAAASIYRGRSVEETEAAHDLLSLSQSLPPLIPPCVVTIMKQEQE 275
            .|.|:|.:.|                      ::||...|                       ||
Human   205 EEEEEEEDDD----------------------DDTEDFAD-----------------------QE 224

  Fly   276 QLRSPEIQEISNSASSRSPQSTIRFIGSSSYDLMGGSSEGANNCSPLTPPNSDHSSD---VDIDM 337
            .|  |:.|:||   ..:||..|...            :|.|.:.:|...|:|..:..   :.:..
Human   225 NL--PDPQDIS---CHQSPSKTDHL------------TEKAYSDTPRDFPDSFQAGSPGHLGVIR 272

  Fly   338 SSSSESGLQQ--WGKPNPQQNQQRASAL----------------------KMCLNMLDGRTKASK 378
            ..|.||.|::  :.|.|....:...|..                      .|....||...|..|
Human   273 DFSIESLLRENLYPKANIPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMDSGPLDLVIKNRK 337

  Fly   379 AAAVTKQDRQEPMQPRPKSAQSNASSGGGPPSEP--------PENPAASLGHSSSGNGENYAKRK 435
                .|::.:|.:.|.|            ||..|        |:.|...||...:.|  :|    
Human   338 ----IKEEEKEELPPPP------------PPPFPNDFFKDMFPDLPGGPLGPIKAEN--DY---- 380

  Fly   436 RGCYKCCECGKQYATSSNLSRHKQTH-------------RSLDSQSAKKCNTCGKAYVSMPALAM 487
             |.|              |:....||             |.|..:::::|..|.|..:....|..
Human   381 -GAY--------------LNFLSATHLGGLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPR 430

  Fly   488 HLLTH--KLSHSCDICGKLFSRPWLLQGHLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDK 550
            |:.||  :..:.|.||...|:|...|:.|:|.||||:||.|:||...|....:|:.||:.|:|.:
Human   431 HMRTHTGEKPYMCTICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVR 495

  Fly   551 NFKCHRCNKTFALKSYLNKHLESACLRDA 579
            .::|..|.|:|....:|::|::....|.|
Human   496 PYQCEFCYKSFTRSDHLHRHIKRQSCRMA 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12605NP_001261387.1 zf-C2H2 439..461 CDD:278523 2/21 (10%)
C2H2 Zn finger 441..461 CDD:275370 1/19 (5%)
C2H2 Zn finger 472..492 CDD:275368 5/19 (26%)
COG5048 492..>570 CDD:227381 29/79 (37%)
zf-C2H2 496..518 CDD:278523 8/21 (38%)
C2H2 Zn finger 498..518 CDD:275368 8/19 (42%)
zf-H2C2_2 511..534 CDD:290200 12/22 (55%)
zf-C2H2 524..546 CDD:278523 8/21 (38%)
C2H2 Zn finger 526..546 CDD:275368 7/19 (37%)
zf-H2C2_2 538..562 CDD:290200 8/23 (35%)
C2H2 Zn finger 554..571 CDD:275368 5/16 (31%)
ZBTB7CXP_016881094.1 BTB 73..176 CDD:279045 17/102 (17%)
BTB 84..177 CDD:197585 13/92 (14%)
C2H2 Zn finger 415..435 CDD:275368 5/19 (26%)
zf-H2C2_2 430..452 CDD:290200 7/21 (33%)
C2H2 Zn finger 443..463 CDD:275368 8/19 (42%)
zf-H2C2_2 456..480 CDD:290200 13/23 (57%)
C2H2 Zn finger 471..491 CDD:275368 7/19 (37%)
zf-H2C2_2 483..508 CDD:290200 9/24 (38%)
C2H2 Zn finger 499..517 CDD:275368 6/17 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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