DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12605 and Scrt1

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_570963.1	Gene:	Scrt1 / 170729	MGIID:	2176606	Length:	348	Species:	Mus musculus

Alignment Length:	301	Identity:	147/301 - (48%)
Similarity:	182/301 - (60%)	Gaps:	38/301 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 FIGSSS-YDLMGGSSEGANNCSPLTPPNSDHSSDVDIDMSSSSESGLQQWGKPNPQQNQQRASAL 363
            ::|.:| ||   |.:|.|....|  .|...:::.|..::..:: ||    ..|.|....:.|:|.
Mouse    44 YVGPASVYD---GDAEAALLKGP--SPEPMYAAAVRGELGPAA-SG----SAPPPTPRPELATAA 98

  Fly   364 KMCLN---------------MLDGRT--KASKAAAVTKQDRQEPMQPRPKSAQSNASSGGGPPSE 411
            ...:|               :.|||:  ||:.|.|..     .|......:..|:|..||||.:.
Mouse    99 GGYINGDAAVSEGYAADAFFITDGRSRRKAANANAAA-----APSTASVAAPDSDAGGGGGPGTR 158

  Fly   412 PPENPAASLGHSSSGNGE-----NYAKRKRGCYKCCECGKQYATSSNLSRHKQTHRSLDSQSAKK 471
            ...:.:||.|.:..|.|.     :.|....|.:.|.||||.||||||||||||||||||||.|::
Mouse   159 GSGSGSASRGGTRVGAGTEARAGSGATGAGGRHACGECGKTYATSSNLSRHKQTHRSLDSQLARR 223

  Fly   472 CNTCGKAYVSMPALAMHLLTHKLSHSCDICGKLFSRPWLLQGHLRSHTGEKPYACVHCGKAFADR 536
            |.||||.||||||:|||||||.|.|.|.:|||.||||||||||:||||||||:.|.|||||||||
Mouse   224 CPTCGKVYVSMPAMAMHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADR 288

  Fly   537 SNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLESACLR 577
            |||||||||||..|:|:|.||.|:||||||||||.||||.:
Mouse   289 SNLRAHMQTHSAFKHFQCKRCKKSFALKSYLNKHYESACFK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	17/21 (81%)
		C2H2 Zn finger	441..461	CDD:275370	17/19 (89%)
		C2H2 Zn finger	472..492	CDD:275368	16/19 (84%)
		COG5048	492..>570	CDD:227381	60/77 (78%)
		zf-C2H2	496..518	CDD:278523	16/21 (76%)
		C2H2 Zn finger	498..518	CDD:275368	15/19 (79%)
		zf-H2C2_2	511..534	CDD:290200	18/22 (82%)
		zf-C2H2	524..546	CDD:278523	18/21 (86%)
		C2H2 Zn finger	526..546	CDD:275368	18/19 (95%)
		zf-H2C2_2	538..562	CDD:290200	16/23 (70%)
		C2H2 Zn finger	554..571	CDD:275368	13/16 (81%)
Scrt1	NP_570963.1	SNAG domain. /evidence=ECO:0000250	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..190		15/64 (23%)
		zf-C2H2	191..213	CDD:278523	17/21 (81%)
		C2H2 Zn finger	193..213	CDD:275368	17/19 (89%)
		C2H2 Zn finger	224..241	CDD:275371	13/16 (81%)
		COG5048	<245..>313	CDD:227381	51/67 (76%)
		zf-C2H2	248..270	CDD:278523	16/21 (76%)
		C2H2 Zn finger	250..270	CDD:275368	15/19 (79%)
		zf-H2C2_2	263..286	CDD:290200	18/22 (82%)
		C2H2 Zn finger	278..298	CDD:275368	18/19 (95%)
		zf-C2H2	278..298	CDD:278523	18/19 (95%)
		zf-H2C2_2	290..314	CDD:290200	16/23 (70%)
		C2H2 Zn finger	306..322	CDD:275368	12/15 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837657
Domainoid	1	1.000	53	1.000	Domainoid score	I11285
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1379
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332418at2759
OrthoFinder	1	1.000	-	-		FOG0000984
OrthoInspector	1	1.000	-	-		mtm8872
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.660