DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12605 and ZBTB49

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001317554.1	Gene:	ZBTB49 / 166793	HGNCID:	19883	Length:	765	Species:	Homo sapiens

Alignment Length:	437	Identity:	113/437 - (25%)
Similarity:	179/437 - (40%)	Gaps:	92/437 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 AASIYRGRSVEETEA---AHDLLSLSQSLPPLIPPCVVTIMKQEQEQLRSPE-------IQEISN 287
            ||...:.|.||:..|   :.||.::...      ||.|:   ..:..|.|||       .|.:::
Human   228 AAGPSQERVVEQPFAFSTSTDLTTVESQ------PCAVS---HSECILESPEHLPSNFLAQPVND 283

  Fly   288 SASSRSPQST------------------IRFIGSSSYDLMGGSSEGANNCSPLTPPNSDHSSDVD 334
            ||......:|                  :.|:.|..|            ...::.|.||  ..:.
Human   284 SAPHPESDATCQQPVKQMRLKKAIHLKKLNFLKSQKY------------AEQVSEPKSD--DGLT 334

  Fly   335 IDMSSSSESGLQQWGKPNPQQNQQRAS-ALKMC--LNMLDGRTKASKAAAVTKQDRQEPMQPRPK 396
            ..:.|:|::.|:   |.:.|..:::.| .:..|  .|.:....:....||:  :|:.:.:|
Human   335 KRLESASKNTLE---KASSQSAEEKESEEVVSCENFNCISETERPEDPAAL--EDQSQTLQ---- 390

  Fly   397 SAQSNASSGGGPPSEPPEN----PAASLGH------------SSSGNGENYAKRKRG--CYKCCE 443
            |.:..|....|.|.:.|.|    ..:..|.            |.:||.:.:.:|..|  .|.|..
Human   391 SQRQYACELCGKPFKHPSNLELHKRSHTGEKPFECNICGKHFSQAGNLQTHLRRHSGEKPYICEI 455

  Fly   444 CGKQYATSSNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPALAMHLLTHKLS--HSCDICGKLFS 506
            |||::|.|.::.||...|   ..:....|:.||:.:.:...|..|..||...  .:||.|||.|:
Human   456 CGKRFAASGDVQRHIIIH---SGEKPHLCDICGRGFSNFSNLKEHKKTHTADKVFTCDECGKSFN 517

  Fly   507 RPWLLQGHLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHL 571
            ....|..|...||||:||:|..|||.|....:||.|::||:|:|.:.|..|||.|...:.|.:|.
Human   518 MQRKLVKHRIRHTGERPYSCSACGKCFGGSGDLRRHVRTHTGEKPYTCEICNKCFTRSAVLRRHK 582

  Fly   572 ESACLRDAGAIDQGKGLEEEDDDCSKQDELEMGDELESDENSQDIVV 618
            :..|  .||  |:...:.||.....:..:||...  .||..|||..|
Human   583 KMHC--KAG--DESPDVLEELSQAIETSDLEKSQ--SSDSFSQDTSV 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275370	8/19 (42%)
		C2H2 Zn finger	472..492	CDD:275368	5/19 (26%)
		COG5048	492..>570	CDD:227381	33/79 (42%)
		zf-C2H2	496..518	CDD:278523	8/21 (38%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	511..534	CDD:290200	12/22 (55%)
		zf-C2H2	524..546	CDD:278523	9/21 (43%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	538..562	CDD:290200	11/23 (48%)
		C2H2 Zn finger	554..571	CDD:275368	6/16 (38%)
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..203
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..294		3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910