DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12605 and AEBP2

DIOPT Version :10

Sequence 1:NP_647845.2 Gene:CG12605 / 38468 FlyBaseID:FBgn0035481 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_001107648.1 Gene:AEBP2 / 121536 HGNCID:24051 Length:517 Species:Homo sapiens


Alignment Length:432 Identity:93/432 - (21%)
Similarity:153/432 - (35%) Gaps:111/432 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 VAAPVSASVSLRRPVGRAPAEDGKVIFYAPPASASGSPRQPEPVALKRERERDKEREREKERERD 220
            :||.::....|......:|...|     :|.::|.|....||        |.::|.|.|:|.|.:
Human     1 MAAAITDMADLEELSRLSPLPPG-----SPGSAARGRAEPPE--------EEEEEEEEEEEAEAE 52

  Fly   221 RMREQQLVAATAAASIYRGRSVEETEAAHDLLSLSQSLPPLIPPCVVTIMKQEQEQLRSPEIQEI 285
            .:....|...:.......|..|...||.    ::|:..|.......   ..:::|:....|..|.
Human    53 AVAALLLNGGSGGGGGGGGGGVGGGEAE----TMSEPSPESASQAG---EDEDEEEDDEEEEDES 110

  Fly   286 SNSASSRSPQSTIRFIGSSSYDLMGGSSEGANNCSP---------------LTPP---------- 325
            |:|.......|....:|||.    |.||:...:.||               |..|          
Human   111 SSSGGGEEESSAESLVGSSG----GSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGG 171

  Fly   326 -NSDHSSDVDIDMSSSSESGLQQWGKPNPQQNQQRASALKMCLNMLDGRTKASKAAAVTKQDRQE 389
             ....||.|   :||..:.|....|..:...:..|..:|:|          :|....:::.|.::
Human   172 GGGSSSSSV---VSSGGDEGYGTGGGGSSATSGGRRGSLEM----------SSDGEPLSRMDSED 223

  Fly   390 PMQPRPKSAQSNASSGGGPPSEPPENPAASLGHSSSGNGENYAKRKRGCYKCC--ECGKQYATSS 452
            .:........|..|||...|:            ..:|.|...:..|...|.||  :|...:.:|.
Human   224 SISSTIMDVDSTISSGRSTPA------------MMNGQGSTTSSSKNIAYNCCWDQCQACFNSSP 276

  Fly   453 NLSRH-KQTHRSLDSQSAKKCNTCGKAYVSMPALAMHLLTHKLSHSCDICGKLFSRP-----WLL 511
            :|:.| :..|  :|.|.       |..:|.            |...|    |:::.|     | |
Human   277 DLADHIRSIH--VDGQR-------GGVFVC------------LWKGC----KVYNTPSTSQSW-L 315

  Fly   512 QGHLRSHTGEKPYACV--HCGKAFADRSNLRAHMQTHSGDKN 551
            |.|:.:|:|:||:.||  .|..:||.:..|..|:.||...:|
Human   316 QRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQN 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12605NP_647845.2 COG5048 283..>561 CDD:227381 68/305 (22%)
zf-C2H2 439..461 CDD:395048 7/24 (29%)
C2H2 Zn finger 441..461 CDD:275370 6/22 (27%)
C2H2 Zn finger 472..492 CDD:275368 2/19 (11%)
zf-C2H2 496..518 CDD:395048 7/26 (27%)
C2H2 Zn finger 498..518 CDD:275368 7/24 (29%)
zf-H2C2_2 511..534 CDD:463886 10/24 (42%)
zf-C2H2 524..546 CDD:395048 7/23 (30%)
C2H2 Zn finger 526..546 CDD:275368 7/21 (33%)
zf-H2C2_2 538..562 CDD:463886 5/14 (36%)
C2H2 Zn finger 554..571 CDD:275368
AEBP2NP_001107648.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..229 51/264 (19%)
Interaction with RBBP4 209..294 22/115 (19%)
COG5048 <215..>339 CDD:227381 36/161 (22%)
C2H2 Zn finger 266..286 CDD:275368 4/19 (21%)
C2H2 Zn finger 297..322 CDD:275368 8/41 (20%)
C2H2 Zn finger 330..352 CDD:275368 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 352..394 2/6 (33%)
Interaction with SUZ12. /evidence=ECO:0000269|PubMed:29499137 407..478
Important for nucleosome binding activity of the PRC2 complex. /evidence=ECO:0000269|PubMed:29499137 495..517
Blue background indicates that the domain is not in the aligned region.

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