DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14983 and RFWD3

DIOPT Version :9

Sequence 1:	NP_647843.1	Gene:	CG14983 / 38466	FlyBaseID:	FBgn0035479	Length:	163	Species:	Drosophila melanogaster
Sequence 2:	NP_001357463.1	Gene:	RFWD3 / 55159	HGNCID:	25539	Length:	774	Species:	Homo sapiens

Alignment Length:	147	Identity:	37/147 - (25%)
Similarity:	64/147 - (43%)	Gaps:	38/147 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EQEKEIQEIILEESFA--SPEQRLAQLESVTSRMHLYHSRRGNILM---SLQQELGKYEYFTLLV 75
            :|.:|...:||||..|  |.||.:..::...:.......::...|:   |:.:|.|
Human   229 DQAEESGAVILEEQLAGVSAEQEVTCIDGGKTLPKQPSPQKSEPLLPSASMDEEEG--------- 284

  Fly    76 RHIAQTHSYLKSLNKALDFLYKVNICSICDLKCEPHGRHSMVSLRCGHLFGRHCINNVLR-ESSR 139
                                   :.|:||..:....|.|.:.:||||||||..||:..|: :..:
Human   285 -----------------------DTCTICLEQWTNAGDHRLSALRCGHLFGYRCISTWLKGQVRK 326

  Fly   140 CPTCSRRARHHEVRRIY 156
            ||.|:::|||.::..:|
Human   327 CPQCNKKARHSDIVVLY 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14983	NP_647843.1	zf-RING_2	99..143	CDD:290367	18/44 (41%)
RFWD3	NP_001357463.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..116
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..225
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..280		2/22 (9%)
		mRING-C3HGC3_RFWD3	283..331	CDD:319364	19/79 (24%)
		WD40	<486..774	CDD:225201
		WD 1	495..537
		WD40 repeat	500..537	CDD:293791
		WD 2	539..577
		WD40 repeat	543..580	CDD:293791
		WD 3	583..628
		WD40 repeat	588..655	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7722
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1451258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.800