DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14982 and FAM110B

DIOPT Version :9

Sequence 1:	NP_001261385.1	Gene:	CG14982 / 38464	FlyBaseID:	FBgn0035477	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001364918.1	Gene:	FAM110B / 90362	HGNCID:	28587	Length:	370	Species:	Homo sapiens

Alignment Length:	387	Identity:	71/387 - (18%)
Similarity:	127/387 - (32%)	Gaps:	138/387 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 GNRSIKSAG-----ESSINRDSGGSSGHYTHRSEPCYKRERQREVAGSAAPASGTIKNCCTLVAA 460
            |:.::|..|     ||.:.|::              .|.|..:.:..|:..:|
Human    94 GSPTLKVFGNHAKTESGVQREN--------------LKLEILKNIINSSEGSS------------ 132

  Fly   461 TRRDSGSSTQHSANSYCGYVTPAGDYSGMGGGRNTECLDCRCKQDTTMGSDYLLNFTPTPEVPEA 525
                |||..:||:.::..:.:.|.|..                                   ..:
Human   133 ----SGSGHKHSSRNWPPHRSEATDLH-----------------------------------RHS 158

  Fly   526 FQDDYTPTPPSPRLKTQTPRYSSS--SSQQLHTSSQGYTSINHSQSSL-----VQSPGSAPSVDD 583
            |.:.....|...|   ::|:...|  ..:.|..|::.:..::||.|.:     |:...:.|....
Human   159 FAESLKVYPTQGR---RSPQEGGSHVGRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSS 220

  Fly   584 ISPPPIQFKRQRCIRFKNRNRLPVQGEMGGPPGSGGGLVAPGSGGMGTASGVLAAYKQHRGSVDH 648
            ..|.|.:.|.......|:....||:                      .|.||.......|...|.
Human   221 APPLPPKPKIAAIASMKSPEADPVE----------------------PACGVSRRPSLQRSKSDL 263

  Fly   649 ENVFFPKGFSSEVYHNSLDMEREALNASISELEKFFDRLGLNDEAFHEIYSQP-RRHHSETDDAS 712
            .:.:|           .:|          :::|:||:..||:.|....:..:. .|.:|:....:
Human   264 SDRYF-----------RVD----------ADVERFFNYCGLDPEELENLGMENFARANSDIISLN 307

  Fly   713 DDSSTVFFSDV-STVDS---MRLPDSTETQ-PQATQAYRPSEPPSIVERNARIIKWLCNCKK 769
            ..|:::..||. .:.||   :|..||...: |....|         :||||||||||.:.|:
Human   308 FRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISA---------IERNARIIKWLYSIKQ 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14982	NP_001261385.1	FAM110_C	663..770	CDD:290865	30/113 (27%)
FAM110B	NP_001364918.1	FAM110_N	13..118	CDD:404949	6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..151		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..256		6/40 (15%)
		FAM110_C	253..361	CDD:404948	33/138 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..337		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28WFT
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326385at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14758
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010