Protein Alignment CG10863 and AKR1B10

DIOPT Version :10

• Sequence 1: NP_647840.1
• Gene: CG10863 / 38463
• FlyBaseID: FBgn0027552
• Length: 316
• Species: Drosophila melanogaster
• Sequence 2: NP_064695.3
• Gene: AKR1B10 / 57016
• HGNCID: 382
• Length: 316
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 136/315 - (43%)
• Similarity: 193/315 - (61%)
• Gaps: 7/315 - (2%)

  Fly     7 YVKHNNGTQIQSIGLGTYTSLGGDCERATLHAIDVGYRHIDTAYFYENENEVGAAVQRKIAEGVI 71
            :|:.:...::..:||||:.|..|..:.|...|||.||||||.||.|:||:|||.|:|.||.|..:
Human     4 FVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAV 68

  Fly    72 KREDIHITTKLWCHFHEPKRVEYACRKTLQNFGLQYVDLYLMHWPYSYVYRGDNEMMPTDAKGEV 136
            ||||:.|.:|||..|.|...|..|..|||::..|.|:|:||:|||..  ::..:::.|.|.||..
Human    69 KREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQG--FKSGDDLFPKDDKGNA 131

  Fly   137 ELNDIDYLDTWREMEKLVELGLTKSIGVSNFNSEQLTRLL--ANCKIKPIHNQIECHPALNQKKL 199
            ......:||.|..||:||:.||.|::|||||:..|:.:||  ...|.||:.||:||||.|.|:||
Human   132 IGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKL 196

  Fly   200 IALCKKNDIVVTAYCPLG---RPNPAEKTPNYIYDAKVQAIGDKYKKSTAQVVLRYLIEIGTIPL 261
            |..|....|.||||.|||   ||....:.|:.:.|.|::.|..|:||:.|||::|:.|:...|.:
Human   197 IQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVI 261

  Fly   262 PKSSNPKRIEENFQIFDFQLDAEDHAILDSYNTGERLIPMTHAIKSKNYPFNIEF 316
            |||..|.||.||.|:|||:|..|:.|.:.|:|...|...:..:...::||||.|:
Human   262 PKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10863	NP_647840.1	AKR_AKR2E1-5	6..299	CDD:381342	131/296 (44%)
AKR1B10	NP_064695.3	AKR_AKR1B1-19	10..316	CDD:381333	134/307 (44%)