Protein Alignment CG10863 and AKR1B1

DIOPT Version :10

• Sequence 1: NP_647840.1
• Gene: CG10863 / 38463
• FlyBaseID: FBgn0027552
• Length: 316
• Species: Drosophila melanogaster
• Sequence 2: NP_001619.1
• Gene: AKR1B1 / 231
• HGNCID: 381
• Length: 316
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 146/311 - (46%)
• Similarity: 201/311 - (64%)
• Gaps: 7/311 - (2%)

  Fly    11 NNGTQIQSIGLGTYTSLGGDCERATLHAIDVGYRHIDTAYFYENENEVGAAVQRKIAEGVIKRED 75
            |||.::..:||||:.|..|....|...||||||||||.|:.|:||||||.|:|.|:.|.|:|||:
Human     8 NNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREE 72

  Fly    76 IHITTKLWCHFHEPKRVEYACRKTLQNFGLQYVDLYLMHWPYSYVYRGDNEMMPTDAKGEVELND 140
            :.|.:||||.:||...|:.||:|||.:..|.|:||||:|||..  ::...|..|.|..|.|..:|
Human    73 LFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTG--FKPGKEFFPLDESGNVVPSD 135

  Fly   141 IDYLDTWREMEKLVELGLTKSIGVSNFNSEQLTRLL--ANCKIKPIHNQIECHPALNQKKLIALC 203
            .:.||||..||:||:.||.|:||:||||..|:..:|  ...|.||..|||||||.|.|:|||..|
Human   136 TNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYC 200

  Fly   204 KKNDIVVTAYCPLG---RPNPAEKTPNYIYDAKVQAIGDKYKKSTAQVVLRYLIEIGTIPLPKSS 265
            :...||||||.|||   ||....:.|:.:.|.:::||..|:.|:||||::|:.::...:.:|||.
Human   201 QSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSV 265

  Fly   266 NPKRIEENFQIFDFQLDAEDHAILDSYNTGERLIPMTHAIKSKNYPFNIEF 316
            .|:||.|||::|||:|.::|...|.|||...|:..:......|:|||:.||
Human   266 TPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10863	NP_647840.1	AKR_AKR2E1-5	6..299	CDD:381342	140/292 (48%)
AKR1B1	NP_001619.1	AKR_AKR1B1-19	10..316	CDD:381333	142/307 (46%)