Protein Alignment CG10863 and AKR1C2

DIOPT Version :10

• Sequence 1: NP_647840.1
• Gene: CG10863 / 38463
• FlyBaseID: FBgn0027552
• Length: 316
• Species: Drosophila melanogaster
• Sequence 2: NP_001345.1
• Gene: AKR1C2 / 1646
• HGNCID: 385
• Length: 323
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 134/325 - (41%)
• Similarity: 190/325 - (58%)
• Gaps: 11/325 - (3%)

  Fly     1 MSSKIPYVKHNNGTQIQSIGLGTYTSL---GGDCERATLHAIDVGYRHIDTAYFYENENEVGAAV 62
            |.||...||.|:|..:..:|.|||...   ......|...||:.|:.|||:|:.|.||.:||.|:
Human     1 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAI 65

  Fly    63 QRKIAEGVIKREDIHITTKLWCHFHEPKRVEYACRKTLQNFGLQYVDLYLMHWPYSYVYRGDNEM 127
            :.|||:|.:|||||..|:|||.:.|.|:.|..|..::|:|..|.||||||:|:|.| |..|: |:
Human    66 RSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVS-VKPGE-EV 128

  Fly   128 MPTDAKGEVELNDIDYLDTWREMEKLVELGLTKSIGVSNFNSEQLTRLL--ANCKIKPIHNQIEC 190
            :|.|..|::..:.:|...||..|||..:.||.|||||||||...|..:|  ...|.||:.||:||
Human   129 IPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVEC 193

  Fly   191 HPALNQKKLIALCKKNDIVVTAYCPLG--RPNP--AEKTPNYIYDAKVQAIGDKYKKSTAQVVLR 251
            ||..||:||:..||..|||:.||..||  |..|  ...:|..:.|..:.|:..|:|::.|.:.||
Human   194 HPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALR 258

  Fly   252 YLIEIGTIPLPKSSNPKRIEENFQIFDFQLDAEDHAILDSYNTGERLIPMTHAIKSKNYPFNIEF 316
            |.::.|.:.|.||.|.:||.:|.|:|:|||.:|:...:|..|...|.:.:.......||||:.|:
Human   259 YQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 323

  Fly   317  316
            Human   324  323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10863	NP_647840.1	AKR_AKR2E1-5	6..299	CDD:381342	126/301 (42%)
AKR1C2	NP_001345.1	AKR_AKR1C1-35	6..308	CDD:381334	126/303 (42%)