DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10863 and AKR1C2

DIOPT Version :9

Sequence 1:NP_647840.1 Gene:CG10863 / 38463 FlyBaseID:FBgn0027552 Length:316 Species:Drosophila melanogaster
Sequence 2:NP_001345.1 Gene:AKR1C2 / 1646 HGNCID:385 Length:323 Species:Homo sapiens


Alignment Length:325 Identity:134/325 - (41%)
Similarity:190/325 - (58%) Gaps:11/325 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSSKIPYVKHNNGTQIQSIGLGTYTSL---GGDCERATLHAIDVGYRHIDTAYFYENENEVGAAV 62
            |.||...||.|:|..:..:|.|||...   ......|...||:.|:.|||:|:.|.||.:||.|:
Human     1 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAI 65

  Fly    63 QRKIAEGVIKREDIHITTKLWCHFHEPKRVEYACRKTLQNFGLQYVDLYLMHWPYSYVYRGDNEM 127
            :.|||:|.:|||||..|:|||.:.|.|:.|..|..::|:|..|.||||||:|:|.| |..|: |:
Human    66 RSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVS-VKPGE-EV 128

  Fly   128 MPTDAKGEVELNDIDYLDTWREMEKLVELGLTKSIGVSNFNSEQLTRLL--ANCKIKPIHNQIEC 190
            :|.|..|::..:.:|...||..|||..:.||.|||||||||...|..:|  ...|.||:.||:||
Human   129 IPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVEC 193

  Fly   191 HPALNQKKLIALCKKNDIVVTAYCPLG--RPNP--AEKTPNYIYDAKVQAIGDKYKKSTAQVVLR 251
            ||..||:||:..||..|||:.||..||  |..|  ...:|..:.|..:.|:..|:|::.|.:.||
Human   194 HPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALR 258

  Fly   252 YLIEIGTIPLPKSSNPKRIEENFQIFDFQLDAEDHAILDSYNTGERLIPMTHAIKSKNYPFNIEF 316
            |.::.|.:.|.||.|.:||.:|.|:|:|||.:|:...:|..|...|.:.:.......||||:.|:
Human   259 YQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 323

  Fly   317  316
            Human   324  323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10863NP_647840.1 ARA1 6..304 CDD:223729 126/306 (41%)
Tas 11..290 CDD:223739 121/287 (42%)
AKR1C2NP_001345.1 AKR_AKR1C1-35 6..308 CDD:381334 126/303 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0656
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53635
OrthoDB 1 1.010 - - D1016440at2759
OrthoFinder 1 1.000 - - FOG0000042
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100072
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X51
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.730

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