Protein Alignment CG10863 and AKR1C4

DIOPT Version :10

• Sequence 1: NP_647840.1
• Gene: CG10863 / 38463
• FlyBaseID: FBgn0027552
• Length: 316
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 137/329 - (41%)
• Similarity: 191/329 - (58%)
• Gaps: 19/329 - (5%)

  Fly     1 MSSKIPYVKHNNGTQIQSIGLGTYTSLGGDCERA---TLHAIDVGYRHIDTAYFYENENEVGAAV 62
            |..|...|:.|:|..:..:|.|||........||   |..||:.|:||||:||.|.||.:||.|:
Human     1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAI 65

  Fly    63 QRKIAEGVIKREDIHITTKLWCHFHEPKRVEYACRKTLQNFGLQYVDLYLMHWPYSYVYRGDNEM 127
            :.|||:|.:|||||..|:||||.|.:|:.|:.|...:|:...|.||||||:|:|.:  .:.....
Human    66 RSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMA--LKPGETP 128

  Fly   128 MPTDAKGEVELNDIDYLDTWREMEKLVELGLTKSIGVSNFNSEQLTRLL--ANCKIKPIHNQIEC 190
            :|.|..|:|..:.:|...||..|||..:.||.|||||||||..||..:|  ...|.||:.||:||
Human   129 LPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVEC 193

  Fly   191 HPALNQKKLIALCKKNDIVVTAYCPLGR--------PNPAEKTPNYIYDAKVQAIGDKYKKSTAQ 247
            ||.|||.||:..||..|||:.|:..||.        ||    :|..:.|..:.|:..|:|::.|.
Human   194 HPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPN----SPVLLEDPVLCALAKKHKQTPAL 254

  Fly   248 VVLRYLIEIGTIPLPKSSNPKRIEENFQIFDFQLDAEDHAILDSYNTGERLIPMTHAIKSKNYPF 312
            :.|||.::.|.:.|.||.|.:||.||.|:|:|||.:||..:||..|...|.:.|...:...:|||
Human   255 IALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFLMDHPDYPF 319

  Fly   313 NIEF 316
            :.|:
Human   320 SDEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10863	NP_647840.1	AKR_AKR2E1-5	6..299	CDD:381342	130/305 (43%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	130/305 (43%)