DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12766 and GCY1

DIOPT Version :9

Sequence 1:	NP_647839.1	Gene:	CG12766 / 38462	FlyBaseID:	FBgn0035476	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_014763.1	Gene:	GCY1 / 854287	SGDID:	S000005646	Length:	312	Species:	Saccharomyces cerevisiae

Alignment Length:	318	Identity:	134/318 - (42%)
Similarity:	182/318 - (57%)	Gaps:	34/318 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NDGTHIQGIGLGTFASTEGDCERAVLHAIDVGYRHIDTAYFYGNEAEVGAAVRKKIAEGVIKRED 76
            |.|..|..|||||:.|.|.|..:|||.|:..||||||||..|.||.:||.|::    :..:.||:
Yeast    15 NTGAQIPQIGLGTWQSKENDAYKAVLTALKDGYRHIDTAAIYRNEDQVGQAIK----DSGVPREE 75

  Fly    77 IFITTKLWC-NFHEPERVEYACRKTLKNIGLDYVDLYLIHWPF----SYKYRGDNELIP--KDAN 134
            ||:|||||| ..|||   |.|..::||.:|||||||||:|||.    :|....|...:|  ||.:
Yeast    76 IFVTTKLWCTQHHEP---EVALDQSLKRLGLDYVDLYLMHWPARLDPAYIKNEDILSVPTKKDGS 137

  Fly   135 GEVELVDIDYLDTWGAMEKLVDLGLTKSIGVSNFNEEQLTRLLAN--CKIKPIHNQIEVHPALDQ 197
            ..|::.:.:::.||..|::|...|.||::|||||:...|..|||:  .|:.|..||:|:||.|.|
Yeast   138 RAVDITNWNFIKTWELMQELPKTGKTKAVGVSNFSINNLKDLLASQGNKLTPAANQVEIHPLLPQ 202

  Fly   198 KKLIALCKKNGILVTAFSPLGRHNAE-LRTPTFMYDGKVQAIADKYNKSIAQVVIRYVIELGTIP 261
            .:||..||..||:|.|:||||..:|. |:.|..:      .||.|.|.....|||.:.::.|.:.
Yeast   203 DELINFCKSKGIVVEAYSPLGSTDAPLLKEPVIL------EIAKKNNVQPGHVVISWHVQRGYVV 261

  Fly   262 LPKSSNPKRIEENFNVFDFKLDAEDHAILD--SYHNGE-RVAHARQAIKSKYYPFNVY 316
            ||||.||.||:.|..:  |.|..||...::  |...|| ||.|      ..:.||.|:
Yeast   262 LPKSVNPDRIKTNRKI--FTLSTEDFEAINNISKEKGEKRVVH------PNWSPFEVF 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12766	NP_647839.1	ARA1	5..298	CDD:223729	128/298 (43%)
CG12766	NP_647839.1	Tas	12..299	CDD:223739	128/299 (43%)
GCY1	NP_014763.1	AKR_AKR3A1-2	7..296	CDD:381343	126/295 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345944
Domainoid	1	1.000	202	1.000	Domainoid score	I552
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I815
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm46528
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1770
SonicParanoid	1	1.000	-	-		X51
TreeFam	0	0.000	Not matched by this tool.
	10	9.720