DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12766 and YPR1

DIOPT Version :9

Sequence 1:	NP_647839.1	Gene:	CG12766 / 38462	FlyBaseID:	FBgn0035476	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_010656.1	Gene:	YPR1 / 851974	SGDID:	S000002776	Length:	312	Species:	Saccharomyces cerevisiae

Alignment Length:	323	Identity:	127/323 - (39%)
Similarity:	177/323 - (54%)	Gaps:	40/323 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KHNDGTHIQGIGLGTFASTEGDCERAVLHAIDVGYRHIDTAYFYGNEAEVGAAVRKKIAEGVIKR 74
            |.|.|..|..:|.||:.|.:.:...:|:.|:..||||||.|..|.||.|||.|::    :..:.|
Yeast    13 KLNTGASIPVLGFGTWRSVDNNGYHSVIAALKAGYRHIDAAAIYLNEEEVGRAIK----DSGVPR 73

  Fly    75 EDIFITTKLWCNFHEPERVEYACRKTLKNIGLDYVDLYLIHWPFSYK----YRGDNELIP--KDA 133
            |:||||||||..  |....|.|..|:||.:|||||||||:|||...|    ..|:...||  :|.
Yeast    74 EEIFITTKLWGT--EQRDPEAALNKSLKRLGLDYVDLYLMHWPVPLKTDRVTDGNVLCIPTLEDG 136

  Fly   134 NGEVELVDIDYLDTWGAMEKLVDLGLTKSIGVSNFNEEQLTRLL--ANCKIKPIHNQIEVHPALD 196
            ..:::..:.:::.||..|::|...|.||::|||||:...:..||  .|.|:.|..||||:||.|.
Yeast   137 TVDIDTKEWNFIKTWELMQELPKTGKTKAVGVSNFSINNIKELLESPNNKVVPATNQIEIHPLLP 201

  Fly   197 QKKLIALCKKNGILVTAFSPLGRHNAELRTPTFMYDGKVQAIAD---KYNKSIAQVVIRYVIELG 258
            |.:|||.||:.||:|.|:||.|..||.|.        |.|||.|   |:....||::|.:.|:.|
Yeast   202 QDELIAFCKEKGIVVEAYSPFGSANAPLL--------KEQAIIDMAKKHGVEPAQLIISWSIQRG 258

  Fly   259 TIPLPKSSNPKRIEENFNVF-----DFKLDAEDHAILDSYHNGERVAHARQAIKSKYYPFNVY 316
            .:.|.||.||:||..||.:|     |||..:.    |...|..:||      :..|:..|.::
Yeast   259 YVVLAKSVNPERIVSNFKIFTLPEDDFKTISN----LSKVHGTKRV------VDMKWGSFPIF 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12766	NP_647839.1	ARA1	5..298	CDD:223729	123/303 (41%)
CG12766	NP_647839.1	Tas	12..299	CDD:223739	122/302 (40%)
YPR1	NP_010656.1	AKR_AKR3A1-2	7..296	CDD:381343	122/300 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345949
Domainoid	1	1.000	202	1.000	Domainoid score	I552
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I815
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm46528
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1770
SonicParanoid	1	1.000	-	-		X51
TreeFam	0	0.000	Not matched by this tool.
	10	9.720