DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12766 and Akr1a1

DIOPT Version :9

Sequence 1:	NP_647839.1	Gene:	CG12766 / 38462	FlyBaseID:	FBgn0035476	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_112262.1	Gene:	Akr1a1 / 78959	RGDID:	68346	Length:	325	Species:	Rattus norvegicus

Alignment Length:	314	Identity:	131/314 - (41%)
Similarity:	193/314 - (61%)	Gaps:	27/314 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IGLGTFASTEGDCERAVLHAIDVGYRHIDTAYFYGNEAEVGAAVRKKIAEG-VIKREDIFITTKL 83
            |||||:.|..|..:.|:.:|:.|||||||.|..||||.|:|.|:::.:..| .:.||::|:|:||
  Rat    17 IGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEALKESVGAGKAVPREELFVTSKL 81

  Fly    84 WCNFHEPERVEYACRKTLKNIGLDYVDLYLIHWPFSYKYRGDNELIPKDANGEVELVDIDYLDTW 148
            |...|.||.||.|.||||.::.|:|:||||:|||:::: ||||. .||:|:|.|:.....|.:||
  Rat    82 WNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFE-RGDNP-FPKNADGTVKYDSTHYKETW 144

  Fly   149 GAMEKLVDLGLTKSIGVSNFNEEQLTRLLANCKIKPIHNQIEVHPALDQKKLIALCKKNGILVTA 213
            .|:|.||..||.|::|:|||:..|:..:|:...::|...|:|.||.|.|.:|||.|:..|:.|||
  Rat   145 KALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTA 209

  Fly   214 FSPLG------RHNAELRTPTFMYDGKVQAIADKYNKSIAQVVIRYVIELGTIPLPKSSNPKRIE 272
            :||||      ||..|   |..:.:..|.|:|:|:.:|.||:::|:.::...|.:|||..|.||.
  Rat   210 YSPLGSSDRAWRHPDE---PVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSITPSRIL 271

  Fly   273 ENFNVFDFKLDAEDHAILDSYH------------NGERVAHARQAIKSKYYPFN 314
            :|..||||....|:...||:.:            :|:||  .|.| ....||||
  Rat   272 QNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRV--PRDA-GHPLYPFN 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12766	NP_647839.1	ARA1	5..298	CDD:223729	123/296 (42%)
CG12766	NP_647839.1	Tas	12..299	CDD:223739	123/297 (41%)
Akr1a1	NP_112262.1	AKR_AKR1A1-4	8..312	CDD:381332	125/301 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690