Protein Alignment CG12766 and AKR1C1

DIOPT Version :10

• Sequence 1: NP_647839.1
• Gene: CG12766 / 38462
• FlyBaseID: FBgn0035476
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_001344.2
• Gene: AKR1C1 / 1645
• HGNCID: 384
• Length: 323
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 136/314 - (43%)
• Similarity: 187/314 - (59%)
• Gaps: 11/314 - (3%)

  Fly    10 KHNDGTHIQGIGLGTFASTE---GDCERAVLHAIDVGYRHIDTAYFYGNEAEVGAAVRKKIAEGV 71
            |.|||..:..:|.||:|..|   .....|...||:.|:||||:|:.|.||.:||.|:|.|||:|.
Human     9 KLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGS 73

  Fly    72 IKREDIFITTKLWCNFHEPERVEYACRKTLKNIGLDYVDLYLIHWPFSYKYRGDNELIPKDANGE 136
            :||||||.|:|||||.|.||.|..|..::|||:.||||||||||:|.|.|  ...|:||||.||:
Human    74 VKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK--PGEEVIPKDENGK 136

  Fly   137 VELVDIDYLDTWGAMEKLVDLGLTKSIGVSNFNEEQLTRLL--ANCKIKPIHNQIEVHPALDQKK 199
            :....:|...||.|:||..|.||.|||||||||..||..:|  ...|.||:.||:|.||..:|:|
Human   137 ILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRK 201

  Fly   200 LIALCKKNGILVTAFSPLGRHNAE----LRTPTFMYDGKVQAIADKYNKSIAQVVIRYVIELGTI 260
            |:..||...|::.|:|.||.|..|    ..:|..:.|..:.|:|.|:.::.|.:.:||.::.|.:
Human   202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVV 266

  Fly   261 PLPKSSNPKRIEENFNVFDFKLDAEDHAILDSYHNGERVAHARQAIKSKYYPFN 314
            .|.||.|.:||.:|..||:|:|.:|:...:|..:...|............|||:
Human   267 VLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFS 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12766	NP_647839.1	AKR_AKR2E1-5	7..299	CDD:381342	132/297 (44%)
AKR1C1	NP_001344.2	AKR_AKR1C1-35	6..308	CDD:381334	133/300 (44%)