DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mge and TOMM22

DIOPT Version :9

Sequence 1:	NP_523910.1	Gene:	mge / 38459	FlyBaseID:	FBgn0035473	Length:	148	Species:	Drosophila melanogaster
Sequence 2:	NP_064628.1	Gene:	TOMM22 / 56993	HGNCID:	18002	Length:	142	Species:	Homo sapiens

Alignment Length:	137	Identity:	58/137 - (42%)
Similarity:	83/137 - (60%)	Gaps:	5/137 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SGMSSLGGSKDETPERRAVAATSNDPQ---RENYDDEPDETASERFWGLTEMFPEPVRNAVGAVS 75
            :.:::.|..:.::|:.......:..|:   .|:.|:|.|||.|||.|||||||||.||:|.||..
Human     3 AAVAAAGAGEPQSPDELLPKGDAEKPEEELEEDDDEELDETLSERLWGLTEMFPERVRSAAGATF 67

  Fly    76 SATVKSVKGFYSFSCNASWIFFTSAVILFAPVIFETERAQMEELHKSQQKQVLLGPGSAMGPGGP 140
            ..::...:..|.||..|.||..||.:||..||:||||:.|||:..:.||:|:||||.:.:..|.|
Human    68 DLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMP 132

  Fly   141 S--PSLP 145
            .  ||||
Human   133 GALPSLP 139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mge	NP_523910.1	Tom22	16..145	CDD:299761	56/133 (42%)
TOMM22	NP_064628.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		6/38 (16%)
		Import sequence, necessary for mitochondrion outer membrane localization and integration in the TOM complex. /evidence=ECO:0000250	41..50		6/8 (75%)
		TMD, necessary for mitochondrion outer membrane localization and integration in the TOM complex. /evidence=ECO:0000250	83..103		10/19 (53%)
		C-tail signal, necessary for mitochondrion outer membrane localization and integration in the TOM complex. /evidence=ECO:0000250	123..142		7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158801
Domainoid	1	1.000	86	1.000	Domainoid score	I8144
eggNOG	1	0.900	-	-		E1_KOG4111
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10638
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4928
Isobase	1	0.950	-	0	Normalized mean entropy	S3758
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1625053at2759
OrthoFinder	1	1.000	-	-		FOG0005739
OrthoInspector	1	1.000	-	-		oto88525
orthoMCL	1	0.900	-	-		OOG6_107973
Panther	1	1.100	-	-	LDO	PTHR12504
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3481
SonicParanoid	1	1.000	-	-		X6220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740