DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sc2 and TECR

DIOPT Version :9

Sequence 1:	NP_647836.2	Gene:	Sc2 / 38457	FlyBaseID:	FBgn0035471	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	XP_024307558.1	Gene:	TECR / 9524	HGNCID:	4551	Length:	371	Species:	Homo sapiens

Alignment Length:	311	Identity:	157/311 - (50%)
Similarity:	200/311 - (64%)	Gaps:	35/311 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 IGDLRALIHKTLKQTPHANRQSLRLELKGKSLKDTDTLESLSLRSGDKIYVKDLGPQIGWKTVFL 90
            |.:::.|..||..|. :..||||||:.|||||||.|.|:.|.:.:...:|.:|||.||.|.||||
Human    62 IAEIKNLFTKTHPQW-YPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFL 125

  Fly    91 AEYAGPLIVYLIFYFRPELVYGKAASLPISLTT--HIAAGCYTVHYVKRLLETIFVHRFSHATMP 153
            .||||||.:||:||||...:||.......|..|  |:|..|::.||:||||||:|||||||.|||
Human   126 TEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMP 190

  Fly   154 LRNLFKNCTYYWGFTAYVSYHVNHPQFTS--------------------------PCMCTVWG-- 190
            |||:||||||||||.|:::|::|||.:|.                          |...:.:|
Human   191 LRNIFKNCTYYWGFAAWMAYYINHPLYTPPSKWPQTILPSPTVPTQRVLPSWAPLPASSSAYGAQ 255

  Fly   191 ----ALGAFALCELGNFSVHIALRNLRPPGTKVRKIPVADGNPLTKLFDLVSCPNYTYEIGAWVS 251
                ||..|.:|:|||||:|:|||:|||.|:|.||||....||.|.||.||||||||||:|:|:.
Human   256 QVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIG 320

  Fly   252 FSVLTSCLAAYLFAFAGAFQMTIWALAKHRNYKKEFKDYPRQRRSIFPFVL 302
            |:::|.||...||:..|..||||||..|||:|.|||:|||..|..|.||:|
Human   321 FAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sc2	NP_647836.2	Tsc13_N	3..79	CDD:176396	22/52 (42%)
		PLN02560	15..299	CDD:178174	154/306 (50%)
		PEMT	150..302	CDD:304400	90/183 (49%)
TECR	XP_024307558.1	PLN02560	55..368	CDD:178174	154/306 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145632
Domainoid	1	1.000	202	1.000	Domainoid score	I3001
eggNOG	1	0.900	-	-		E1_KOG1639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36231
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2450
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S1292
OMA	1	1.010	-	-		QHG53957
OrthoDB	1	1.010	-	-		D537031at33208
OrthoFinder	1	1.000	-	-		FOG0001630
OrthoInspector	1	1.000	-	-		otm41880
orthoMCL	1	0.900	-	-		OOG6_102127
Panther	1	1.100	-	-	O	PTHR10556
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2319
SonicParanoid	1	1.000	-	-		X1032
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750