DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sc2 and tecra

DIOPT Version :9

Sequence 1:	NP_647836.2	Gene:	Sc2 / 38457	FlyBaseID:	FBgn0035471	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	XP_001921351.1	Gene:	tecra / 566085	ZFINID:	ZDB-GENE-090930-1	Length:	346	Species:	Danio rerio

Alignment Length:	315	Identity:	155/315 - (49%)
Similarity:	206/315 - (65%)	Gaps:	25/315 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELEILNAKNSKPYGKV----KVPSGATPIGDLRALIHKTLKQTPH--ANRQSLRLELKGKSLKDT 60
            |:|||:.|..:   |:    ||...|| |.|::::.||:   .||  ..||||.|:.|||.|||.
Zfish    43 EVEILDVKTRE---KLLLLDKVEPTAT-ILDIKSMFHKS---NPHWYPARQSLCLDPKGKPLKDE 100

  Fly    61 DTLESLSLRSGDKIYVKDLGPQIGWKTVFLAEYAGPLIVYLIFYFRPELVYGKAASLPIS--LTT 123
            |.|:.|.:.:....|.:|||.||.|.||||.|..|||::||:||||..|:|........|  |..
Zfish   101 DILQELPVGTTATFYFRDLGAQIAWGTVFLIECIGPLVLYLLFYFRLPLIYAPKYDFTASKHLVV 165

  Fly   124 HIAAGCYTVHYVKRLLETIFVHRFSHATMPLRNLFKNCTYYWGFTAYVSYHVNHPQFTSPCMCTV 188
            |||..|:|.||.||::||:|||||||.|||.||:||||.|:|.|.|:::|::|||.:|:|    .
Zfish   166 HIACACHTFHYAKRIMETLFVHRFSHGTMPFRNIFKNCIYHWCFAAWMAYYINHPLYTTP----Y 226

  Fly   189 WG------ALGAFALCELGNFSVHIALRNLRPPGTKVRKIPVADGNPLTKLFDLVSCPNYTYEIG 247
            :|      |||.|..|:||:||:|:|||:|:.||:|.:|||....||.|.:|.||||||||||:|
Zfish   227 YGEKQVKTALGIFLFCQLGSFSIHMALRSLKLPGSKTKKIPYPTKNPFTWIFALVSCPNYTYEVG 291

  Fly   248 AWVSFSVLTSCLAAYLFAFAGAFQMTIWALAKHRNYKKEFKDYPRQRRSIFPFVL 302
            :|:.|:::|.|:....|...|..|||:||..|||:|.||||:||..|..|.||||
Zfish   292 SWLGFTLMTQCVPVLFFTVVGFIQMTVWAKGKHRSYLKEFKEYPTLRSPILPFVL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sc2	NP_647836.2	Tsc13_N	3..79	CDD:176396	30/81 (37%)
		PLN02560	15..299	CDD:178174	146/297 (49%)
		PEMT	150..302	CDD:304400	80/157 (51%)
tecra	XP_001921351.1	Tsc13_N	44..119	CDD:176396	30/81 (37%)
		PLN02560	61..343	CDD:178174	144/289 (50%)
		PEMT	193..346	CDD:304400	80/156 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579026
Domainoid	1	1.000	203	1.000	Domainoid score	I2917
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2412
OMA	1	1.010	-	-		QHG53957
OrthoDB	1	1.010	-	-		D537031at33208
OrthoFinder	1	1.000	-	-		FOG0001630
OrthoInspector	1	1.000	-	-		otm25337
orthoMCL	1	0.900	-	-		OOG6_102127
Panther	1	1.100	-	-	O	PTHR10556
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1032
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910