DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sc2 and Tecrl

DIOPT Version :9

Sequence 1:	NP_647836.2	Gene:	Sc2 / 38457	FlyBaseID:	FBgn0035471	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001102330.1	Gene:	Tecrl / 364134	RGDID:	1304608	Length:	361	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	121/306 - (39%)
Similarity:	182/306 - (59%)	Gaps:	8/306 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELEILNAKNSKPYGKVKVPSGATPIGDLRALIHKTLKQTPHANRQSLRLELKGKSLKDTDTLESL 66
            |:|||:|...|....|...:..:.|.|::...||...:. :.:|..|:||..|..|||..|::|:
  Rat    59 EIEILDAHTRKQICIVDKVTQTSTIYDVKQKFHKACPKW-YPSRIGLQLEYGGPYLKDYITIQSV 122

  Fly    67 SLRSGDKIYVKDLGPQIGWKTVFLAEYAGPLIVYLIFYFRPELVYGKAASL--PISLTTHIAAGC 129
            :..|...:|..|||.|:||.|||||||:|||::||:||.|...:|....|.  |.....|:|..|
  Rat   123 AASSIITLYFTDLGQQVGWTTVFLAEYSGPLLIYLLFYLRSSYIYDVKESFRWPRHTVVHLACFC 187

  Fly   130 YTVHYVKRLLETIFVHRFSHATMPLRNLFKNCTYYWGFTAYVSYHVNHPQFTSPCMCT---VWGA 191
            :.:||::.||||:|||:.|....|::||.|.|.:|||||::::|::|||::|.|....   :..|
  Rat   188 HCIHYIRLLLETLFVHKVSTGHSPMKNLIKGCAFYWGFTSWMAYYINHPRYTPPSFGNRQIIVSA 252

  Fly   192 LGAFALCELGNFSVHIALRNLRPPGTKVRKIPVADGNPLTKLFDLVSCPNYTYEIGAWVSFSVLT 256
            :. |.:||.||..::..|.:....|:.. ..|....||.|.:|.||||||||||||.|:||:::|
  Rat   253 IN-FLMCEAGNHFINTVLAHPSHTGSNA-CFPSPTYNPFTWMFFLVSCPNYTYEIGTWISFTIMT 315

  Fly   257 SCLAAYLFAFAGAFQMTIWALAKHRNYKKEFKDYPRQRRSIFPFVL 302
            ..|...:|......||::||..||:.|:|:|..|..::.:|.||:|
  Rat   316 QTLPVGIFTMLMTIQMSLWARKKHKIYRKKFNSYVHRKSAIIPFIL 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sc2	NP_647836.2	Tsc13_N	3..79	CDD:176396	22/75 (29%)
		PLN02560	15..299	CDD:178174	112/288 (39%)
		PEMT	150..302	CDD:304400	60/154 (39%)
Tecrl	NP_001102330.1	UBQ	60..135	CDD:294102	22/75 (29%)
		PLN02560	77..361	CDD:178174	113/286 (40%)
		PEMT	210..361	CDD:304400	60/152 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339324
Domainoid	1	1.000	133	1.000	Domainoid score	I4926
eggNOG	1	0.900	-	-		E1_KOG1639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2377
OMA	1	1.010	-	-		QHG53957
OrthoDB	1	1.010	-	-		D537031at33208
OrthoFinder	1	1.000	-	-		FOG0001630
OrthoInspector	1	1.000	-	-		otm46017
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10556
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1032
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.870