DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sc2 and Tecr

DIOPT Version :9

Sequence 1:	NP_647836.2	Gene:	Sc2 / 38457	FlyBaseID:	FBgn0035471	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	XP_038953381.1	Gene:	Tecr / 191576	RGDID:	620376	Length:	342	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	166/313 - (53%)
Similarity:	214/313 - (68%)	Gaps:	21/313 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELEILNAKNSKPYGKV----KVPSGATPIGDLRALIHKTLKQTPHANRQSLRLELKGKSLKDTDT 62
            |:||.:||..:   |:    ||...|| |.:::.|..||..|. :..||||||:.|||||||.|.
  Rat    39 EVEIRDAKTRE---KLCFLDKVEPQAT-ISEIKTLFTKTHPQW-YPARQSLRLDPKGKSLKDEDV 98

  Fly    63 LESLSLRSGDKIYVKDLGPQIGWKTVFLAEYAGPLIVYLIFYFRPELVYGKAASLPISLTT--HI 125
            |:.|.:.:...:|.:|||.||.|.||||.||||||.:||:||||...:||:......|..|  |:
  Rat    99 LQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHL 163

  Fly   126 AAGCYTVHYVKRLLETIFVHRFSHATMPLRNLFKNCTYYWGFTAYVSYHVNHPQFTSPCMCTVWG 190
            |..|::.||:||||||:|||||||.||||||:||||||||||.|:::|::|||.:|.|    .:|
  Rat   164 ACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPP----TYG 224

  Fly   191 ------ALGAFALCELGNFSVHIALRNLRPPGTKVRKIPVADGNPLTKLFDLVSCPNYTYEIGAW 249
                  ||..|.:|:|||||:|:|||:|||.|:|.||||....||.|.||.||||||||||:|:|
  Rat   225 VQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSW 289

  Fly   250 VSFSVLTSCLAAYLFAFAGAFQMTIWALAKHRNYKKEFKDYPRQRRSIFPFVL 302
            :.|:::|.|:...||:..|..||||||..|||:|.|||:|||..|..|.||:|
  Rat   290 IGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sc2	NP_647836.2	Tsc13_N	3..79	CDD:176396	31/79 (39%)
		PLN02560	15..299	CDD:178174	158/295 (54%)
		PEMT	150..302	CDD:304400	89/157 (57%)
Tecr	XP_038953381.1	PLN02560	57..339	CDD:178174	156/287 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339325
Domainoid	1	1.000	201	1.000	Domainoid score	I2927
eggNOG	1	0.900	-	-		E1_KOG1639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36231
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2377
OMA	1	1.010	-	-		QHG53957
OrthoDB	1	1.010	-	-		D537031at33208
OrthoFinder	1	1.000	-	-		FOG0001630
OrthoInspector	1	1.000	-	-		otm46017
orthoMCL	1	0.900	-	-		OOG6_102127
Panther	1	1.100	-	-	O	PTHR10556
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1032
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770