DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubi-p63E and ubqln4

DIOPT Version :9

Sequence 1:	NP_001261383.1	Gene:	Ubi-p63E / 38456	FlyBaseID:	FBgn0003943	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_998521.2	Gene:	ubqln4 / 334337	ZFINID:	ZDB-GENE-030131-6269	Length:	599	Species:	Danio rerio

Alignment Length:	687	Identity:	131/687 - (19%)
Similarity:	235/687 - (34%)	Gaps:	172/687 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKES 65
            :::.|||...|. .:.:....::...|.:|..:.....||..||||||.|:||.||..:.|:...
Zfish    26 IKVTVKTPKDKE-EIAIAEDASVAQFKEEISKRFKAKQDQLVLIFAGKILKDGDTLGQHGIKDGL 89

  Fly    66 TLHLVLRL------RGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIP--------PDQ 116
            |:|||::.      .|..|....:..|.:   :..||.|.....|   ...|.|        |.|
Zfish    90 TVHLVIKTAQKTSGAGSSQTSASSGPGPS---QGSPSGTDTPSPA---GNLGTPQGSGPSPTPSQ 148

  Fly   117 QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAK 181
            ...|.||  ..|...||:..:...:.:.|..:::..:....:.|           |..:||  ..
Zfish   149 PANILAG--FGDLSGLSNLGMGSANFMELQQQMQRQLMSNPEML-----------SQIMEN--PL 198

  Fly   182 IQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVE 246
            :|.....|...:::|.|..|::.   |.:.|.:....|:....:|            :|:.|...
Zfish   199 VQSMMSNPDLMRQMIMANPQMQQ---LMERNPEISHMLNNPELMR------------QTMELARN 248

  Fly   247 PS---DTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIF 308
            |:   :.:.|....:.:.|.||.....|         .|..:|.    :..:....|.:.|...|
Zfish   249 PAMMQEMMRNQDRALSNLESIPGGYNAL---------RRMYTDI----QEPMFSAAREQFGNNPF 300

  Fly   309 VKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHL 373
             ..|.|.......:||.| || :..:.:..|.|........:|.......|.|.......:.|.:
Zfish   301 -SALGGNGENPGTQPSRT-EN-REPLPNPWGPPDGTASTTSSGTPTTTSSTTSSTTPSVSNPLGI 362

  Fly   374 VLRLRG-------GMQIFVKTLTGKTITLEVEPSDTIEN------VKAKIQDKEGIPPDQQRL-- 423
            .....|       |||..::.::        |....::|      ::..:|.....|....::
Zfish   363 SSSNLGNGMFNSPGMQSLMQQIS--------ENPQLMQNMISAPYMRTMMQSLAQNPDVASQVLM 419

  Fly   424 ---IFAGK-QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTG-KTITLEVEPSDTIENVK 483
               :|||. ||::                   ::|..:.:|::.:.. :.:::...|    ..::
Zfish   420 NNPLFAGNPQLQE-------------------QMRQQLPVFLQQMQNPEALSVMTNP----RAMR 461

  Fly   484 AKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL---TGKTI 545
            |.:|.:||:...|.........|..|                  .:.||:.:.:...   ||.|:
Zfish   462 ALMQIQEGLQTLQTEAPGLMPGLGPG------------------GMPGGIPVGMPGAPLPTGVTV 508

  Fly   546 TLEVEPSDTIENVKAKIQDKEGIPPDQQRL------IFAG-------------KQLEDGRTLSDY 591
            |.|..|.....:...   ...|..|.||:|      :|||             :|||....:...
Zfish   509 TPENPPPSGQGSTPT---PTAGASPAQQQLMQQMLQMFAGGSASTQTPEVRFQQQLEQLSAMGFI 570

  Fly   592 NIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPS 628
            |  :|:.|..::...|.:...::.|.|.      :||
Zfish   571 N--REANLQALIATGGDINAAIERLLGS------QPS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubi-p63E	NP_001261383.1	Ubiquitin	1..76	CDD:176398	24/80 (30%)
		UBQ	1..72	CDD:214563	24/70 (34%)
		Ubiquitin	77..152	CDD:176398	17/82 (21%)
		UBQ	77..148	CDD:214563	17/78 (22%)
		Ubiquitin	153..228	CDD:176398	13/74 (18%)
		UBQ	153..224	CDD:214563	12/70 (17%)
		Ubiquitin	229..304	CDD:176398	11/77 (14%)
		UBQ	229..300	CDD:214563	10/73 (14%)
		Ubiquitin	305..380	CDD:176398	15/81 (19%)
		UBQ	305..376	CDD:214563	14/70 (20%)
		Ubiquitin	381..456	CDD:176398	12/86 (14%)
		UBQ	381..452	CDD:214563	11/82 (13%)
		Ubiquitin	457..532	CDD:176398	9/75 (12%)
		UBQ	457..528	CDD:214563	9/71 (13%)
		Ubiquitin	533..608	CDD:176398	20/96 (21%)
		UBQ	533..604	CDD:214563	20/92 (22%)
		Ubiquitin	609..684	CDD:176398	4/20 (20%)
		UBQ	609..680	CDD:214563	4/20 (20%)
		Ubiquitin	685..760	CDD:176398
		UBQ	685..756	CDD:214563
ubqln4	NP_998521.2	UBQ	26..96	CDD:214563	24/70 (34%)
		hPLIC_N	26..96	CDD:176403	24/70 (34%)
		STI1	186..223	CDD:128966	9/52 (17%)
		UBA_PLICs	556..595	CDD:270582	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900