DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ccz1 and Ccz1

DIOPT Version :9

Sequence 1:	NP_647835.1	Gene:	Ccz1 / 38455	FlyBaseID:	FBgn0035470	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_808350.1	Gene:	Ccz1 / 231874	MGIID:	2141070	Length:	480	Species:	Mus musculus

Alignment Length:	497	Identity:	150/497 - (30%)
Similarity:	258/497 - (51%)	Gaps:	62/497 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LRSFYIFNSTFGQVEGEEHKKVLFYHPNDIELNTKIKDVGLSEAIIRFTGTFTSEDDCQALHTQK 76
            |.||:|:|..||..||||..|:||||||::|.|.||::|||.|||::||.||:.....::|||||
Mouse    22 LLSFFIYNPRFGPREGEEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQK 86

  Fly    77 TTQLFYQPEPGYWLVLVLNVP-KEVRLKEGVEVADYRGAEISDRIYRAILRQCYQMFRFQNGCFS 140
            ..|.|.:||..:|:|:|:..| .|.:.|:|..|.:|:..|:.|::|.::|:|||.|::..||.|.
Mouse    87 NRQFFNEPEENFWMVMVVRNPIIEKQSKDGKAVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFL 151

  Fly   141 SCGSEEPNPDKRRELLCQKLLQFYDQHLTNLRDPAQCDIIDMLHSIQYLPLDKTLFLRAQNF-GT 204
                 :...|...:||.::|.:|:.::|..|. ...||::|:...|.:.||||..:|:.|:| ..
Mouse   152 -----KAMEDGGVKLLKERLEKFFHRYLQTLH-LQSCDLLDIFGGISFFPLDKMTYLKIQSFINR 210

  Fly   205 LCETFPDIKESIMLYQEQVLCGGKLSPEDLHCVHSYVVQHVLKVEASSSTIAVSPSLKRSISECQ 269
            :.|:...:|.:..||.:|::..| |..:|:..::.|:            |.::.|   |.|....
Mouse   211 MEESLSVVKYTAFLYNDQLIWSG-LEQDDMRILYKYL------------TTSLFP---RHIEPEL 259

  Fly   270 VGGFVRSRQKVAGD-EH------DAVNEEDHPM-----KVYVTLDKEAKPYYLLIYRALHITLCL 322
            .|.....|.::.|: :|      ..:|..|...     |::|..|...:..:|::|:|:...:|.
Mouse   260 AGRDSPVRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCF 324

  Fly   323 FLNADQVAP-KQDLYDDLHAYMAPQLTSLARDISSE--LTKEAVGAAGQDNSSGNSETAP--KYL 382
            .::|.  .| ..|....|.:.:.||||.||.||..:  :.|...|          ||..|  |::
Mouse   325 MIDAS--TPLTLDFCRRLDSIVGPQLTVLASDICEQFNINKRISG----------SEKEPQFKFI 377

  Fly   383 FINEQSL-QHHTNFQRHLPQ----GLPRNVLSIIADLANGSGKAEMESAPAEEVQVKTTNDYWIV 442
            :.|..:| :..|...|..|.    .:..:::.|:.|:.:...:|:.:    ||:.||..:|||:|
Mouse   378 YFNHMNLAEKSTIHMRKTPSVSLTSVHPDLMKILGDINSDFTRADED----EEIIVKAMSDYWVV 438

  Fly   443 KRRCNYRQYYVILCNSKATLLDVTQEARRIFEQELTDDVFFD 484
            .::.:.|:.||||....|.|::|.:|.:::...:..:..|.|
Mouse   439 GKKSDQRELYVILSQKNANLIEVNEEVKKLCATQFNNIFFLD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ccz1	NP_647835.1	DUF1712	15..482	CDD:254668	146/490 (30%)
Ccz1	NP_808350.1	DUF1712	25..477	CDD:254668	145/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845499
Domainoid	1	1.000	184	1.000	Domainoid score	I3409
eggNOG	1	0.900	-	-		E1_KOG2622
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56717
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3504
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55658
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004216
OrthoInspector	1	1.000	-	-		oto92716
orthoMCL	1	0.900	-	-		OOG6_103803
Panther	1	1.100	-	-	LDO	PTHR13056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4421
SonicParanoid	1	1.000	-	-		X2963
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790