DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Awh and LHX2

DIOPT Version :9

Sequence 1:	NP_001261379.1	Gene:	Awh / 38451	FlyBaseID:	FBgn0013751	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens

Alignment Length:	356	Identity:	105/356 - (29%)
Similarity:	161/356 - (45%)	Gaps:	92/356 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKADYSKNFGA-KCSK 71
            ||.||..||||::|......||..||:||.|...|:.:.:||.::..:|||.||.:.|.. :|::
Human    53 CAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCAR 117

  Fly    72 CCRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDDRVLCKAHYLETVEG------- 129
            |..|||||:.|.|||:||:||.||.|..|.:.|:||:.|.:.|..|.|:.|:...::|
Human   118 CHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFN 182

  Fly   130 -----------------------------------GTT---------SSDEGCD----------- 139
                                               ||.         |...|.|
Human   183 HADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCN 247

  Fly   140 -GDGYH---------KSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDLERIASVTGLSKRVTQV 194
             .|..|         ..||||:||:|...||:.:::.|.|:.|||.:||:::|..|||:|||.||
Human   248 ENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQV 312

  Fly   195 WFQNSRARQKKHI----HAGKNKIRE-------PEGSSFARHINLQLTYSFQNNAQNPMHLNGSK 248
            ||||:||:.::::    :.|.:|..:       |.|.:      .:|:.:..:.:..|..|....
Human   313 WFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPA------SELSNASLSPSSTPTTLTDLT 371

  Fly   249 AGLYPTHESSMDELSQDSSVH--CMPSEVXL 277
            :...||..|.:..:..:...|  ..||:. |
Human   372 SPTLPTVTSVLTSVPGNLEGHEPHSPSQTTL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	22/52 (42%)
		LIM2_AWH	69..123	CDD:188765	26/53 (49%)
		Homeobox	152..204	CDD:278475	27/51 (53%)
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	22/52 (42%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	26/57 (46%)
		COG5576	<247..378	CDD:227863	41/136 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/19 (32%)
		Homeobox	270..323	CDD:395001	27/52 (52%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		11/15 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		7/51 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910