DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Awh and LHX4

DIOPT Version :9

Sequence 1:	NP_001261379.1	Gene:	Awh / 38451	FlyBaseID:	FBgn0013751	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_203129.1	Gene:	LHX4 / 89884	HGNCID:	21734	Length:	390	Species:	Homo sapiens

Alignment Length:	228	Identity:	91/228 - (39%)
Similarity:	131/228 - (57%)	Gaps:	25/228 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ELRSCAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPL-DRQQSCFIRERQVYCKADYSKNFGA 67
            ::..||.|.:.|.|:|.|:|....||:.||:|..|...| ||   ||.|...||||.|:.|.||.
Human    26 QIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADR---CFSRAGSVYCKEDFFKRFGT 87

  Fly    68 KCSKCCRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDD-RVLCKAHYLETVEGGT 131
            ||:.|.:||..:..||:|::.|:||.||||..|.|||:||::|.||:| |::||..| ||.:...
Human    88 KCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDY-ETAKQND 151

  Fly   132 TSSDEGCDGDGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDLERIASVTGLSKRVTQVWF 196
            .|           ::..||.|||.|.:||:.|:..::....|.....|:::|.|||..||.||||
Human   152 DS-----------EAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWF 205

  Fly   197 QNSRARQKK-HIHAGKNK-------IREPEGSS 221
            ||.||::|: ...||:::       ::...|||
Human   206 QNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSS 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	24/53 (45%)
		LIM2_AWH	69..123	CDD:188765	27/54 (50%)
		Homeobox	152..204	CDD:278475	23/51 (45%)
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852	24/53 (45%)
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	27/54 (50%)
		Homeobox	160..213	CDD:306543	23/52 (44%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536	161..181		7/19 (37%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305\|PubMed:28473536	199..211		9/11 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910