DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Awh and SHOX2

DIOPT Version :9

Sequence 1:	NP_001261379.1	Gene:	Awh / 38451	FlyBaseID:	FBgn0013751	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_003021.3	Gene:	SHOX2 / 6474	HGNCID:	10854	Length:	355	Species:	Homo sapiens

Alignment Length:	139	Identity:	44/139 - (31%)
Similarity:	64/139 - (46%)	Gaps:	15/139 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 EGCDGDGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDLERIASVTGLSKRVTQVWFQNSR 200
            :|.:.:|..|.|.:|.||.||.|||..|:..|.....||....|.::...|||:...||||||.|
Human   152 KGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRR 216

  Fly   201 A---RQKKHIHAGK--NKIREPEGSSFARHINL-QLTYSFQNNAQNPMHLNGSKAGLYPTHESSM 259
            |   :|:..:|.|.  ....:.|....|.::|: .|...||.::    |.|     :.|......
Human   217 AKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDS----HCN-----VTPLSFQVQ 272

  Fly   260 DELSQDSSV 268
            .:|..||:|
Human   273 AQLQLDSAV 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759
		LIM2_AWH	69..123	CDD:188765
		Homeobox	152..204	CDD:278475	23/54 (43%)
SHOX2	NP_003021.3	Homeobox	167..220	CDD:306543	23/52 (44%)
SHOX2	NP_003021.3	OAR	335..351	CDD:309087
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940