DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Awh and PITX3

DIOPT Version :9

Sequence 1:	NP_001261379.1	Gene:	Awh / 38451	FlyBaseID:	FBgn0013751	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_005020.1	Gene:	PITX3 / 5309	HGNCID:	9006	Length:	302	Species:	Homo sapiens

Alignment Length:	123	Identity:	41/123 - (33%)
Similarity:	56/123 - (45%)	Gaps:	5/123 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 CKAHYLETVEGGTTSSDEGCDGDGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDLERIAS 183
            ||.......|..:.|...|...||..|.|.:|.||.||.:|||.|:|.||.:..||....|.||.
Human    33 CKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAV 97

  Fly   184 VTGLSKRVTQVWFQNSRARQKKHIHAG-----KNKIREPEGSSFARHINLQLTYSFQN 236
            .|.|::...:|||:|.||:.:|...:.     |.....|.|.....:..:...||:.|
Human    98 WTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGN 155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759
		LIM2_AWH	69..123	CDD:188765	2/3 (67%)
		Homeobox	152..204	CDD:278475	24/51 (47%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		13/37 (35%)
		Homeobox	66..119	CDD:395001	24/52 (46%)
		OAR	258..275	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940