DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Awh and LHX8

DIOPT Version :9

Sequence 1:	NP_001261379.1	Gene:	Awh / 38451	FlyBaseID:	FBgn0013751	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	XP_016856805.1	Gene:	LHX8 / 431707	HGNCID:	28838	Length:	363	Species:	Homo sapiens

Alignment Length:	285	Identity:	115/285 - (40%)
Similarity:	161/285 - (56%)	Gaps:	42/285 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKADYSKNFGAKCSKC 72
            |.:||..|.|::.|:|....||..||.|.:|...|.|..||:|:::.::||.||.:.:|.:||:|
Human    65 CNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRC 129

  Fly    73 CRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDDRVLCKAHY-------LETVEGG 130
            .|.|.::||||||:..|:|||||||..|.|||||||:|||::::|||:.||       ...||.|
Human   130 GRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENG 194

  Fly   131 TTSSDEGC---DGDGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDLERIASVTGLSKRVT 192
            ...|.||.   :.|..|....||.||:||.:||||:||.|..|:|||.|.|:::|..||||:||.
Human   195 NGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVI 259

  Fly   193 QVWFQNSRARQKKHI---HAGKNKI-------------REPEGSSFARHINLQLT--YSFQNNAQ 239
            ||||||.|||.|||:   |:....:             .|...|::.......||  :|:.::..
Human   260 QVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDDTH 324

  Fly   240 NPMHL--------------NGSKAG 250
            ..:|:              |||.:|
Human   325 AAVHIHLPGRMWRFQGYSNNGSSSG 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	20/52 (38%)
		LIM2_AWH	69..123	CDD:188765	33/53 (62%)
		Homeobox	152..204	CDD:278475	33/51 (65%)
LHX8	XP_016856805.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8268
eggNOG	1	0.900	-	-		E33208_3BHYC
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62661
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3532
Isobase	1	0.950	-	0	Normalized mean entropy	S3139
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1161127at2759
OrthoFinder	1	1.000	-	-		FOG0001821
OrthoInspector	1	1.000	-	-		otm41383
orthoMCL	1	0.900	-	-		OOG6_108984
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	1	1.000	-	-		X1183
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810