Protein Alignment Awh and LMX1B

DIOPT Version :10

• Sequence 1: NP_001261379.1
• Gene: Awh / 38451
• FlyBaseID: FBgn0013751
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_001167617.1
• Gene: LMX1B / 4010
• HGNCID: 6654
• Length: 406
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 106/305 - (34%)
• Similarity: 139/305 - (45%)
• Gaps: 56/305 - (18%)

  Fly     8 CAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKADYSKNFGAKCSKC 72
            |..|..||||||.:.|...|||..||:|..|...|  ..||:.|:|::|||.||.:.|.||||.|
Human    56 CEGCQRPISDRFLMRVNESSWHEECLQCAACQQAL--TTSCYFRDRKLYCKQDYQQLFAAKCSGC 118

  Fly    73 CRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDDRVLCKAHY-------------- 123
            ...|:.:::|.||.|.|:||.||.|..|.|||..|::|.|.:.::|||..|
Human   119 MEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVSPDE 183

  Fly   124 -----LETVEG------GTTSSDEGCDGDGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQD 177
                 .|..:|      |..|..:|...||....:.||.||..|.:|.:..:|:|::.|.|..:.
Human   184 SDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKV 248

  Fly   178 LERIASVTGLSKRVTQVWFQNSRARQKKHIHAGKNKIREPEGSSFARHINLQLTYSFQNNAQNPM 242
            .|.:|:.||||.||.||||||.||:.||                      |...:..|...||..
Human   249 RETLAAETGLSVRVVQVWFQNQRAKMKK----------------------LARRHQQQQEQQNSQ 291

  Fly   243 HLN----GSKAGLYPTHESSMDELSQDSSVHCMPSE---VXLEQS 280
            .|.    |...||.....||..|....|.....|.:   | :|||
Human   292 RLGQGEPGPGQGLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQS 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	24/52 (46%)
		LIM2_AWH	69..123	CDD:188765	24/53 (45%)
		Homeodomain	149..205	CDD:459649	26/55 (47%)
LMX1B	NP_001167617.1	LIM1_Lmx1b	56..108	CDD:188757	25/53 (47%)
		LIM2_Lmx1a_Lmx1b	115..169	CDD:188764	24/53 (45%)
		Homeodomain	220..276	CDD:459649	26/55 (47%)