Protein Alignment Awh and LMX1A

DIOPT Version :10

• Sequence 1: NP_001261379.1
• Gene: Awh / 38451
• FlyBaseID: FBgn0013751
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_796372.1
• Gene: LMX1A / 4009
• HGNCID: 6653
• Length: 382
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 95/295 - (32%)
• Similarity: 142/295 - (48%)
• Gaps: 55/295 - (18%)

  Fly     8 CAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKADYSKNFGAKCSKC 72
            |..|...|.|||.|.:....||..|::|..|..||  :.:||.|::::|||.||.|.|..||..|
Human    35 CEGCQRVILDRFLLRLNDSFWHEQCVQCASCKEPL--ETTCFYRDKKLYCKYDYEKLFAVKCGGC 97

  Fly    73 CRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDDRVLCKAHYLETVE--------- 128
            ...|:.:::|.||::.|:||:||.|..|.|||..|::|.|.:.::|||..|.:..|
Human    98 FEAIAPNEFVMRAQKSVYHLSCFCCCVCERQLQKGDEFVLKEGQLLCKGDYEKERELLSLVSPAA 162

  Fly   129 ------------------GGTTSSDEGCDGDGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDG 175
                              .|..:::||.|    || :.||.||..|.:|.:..:|:|::.|.|..
Human   163 SDSGKSDDEESLCKSAHGAGKGTAEEGKD----HK-RPKRPRTILTTQQRRAFKASFEVSSKPCR 222

  Fly   176 QDLERIASVTGLSKRVTQVWFQNSRARQKKHIHAGKNKIREPEGSSFARHINLQLTYSFQNNAQN 240
            :..|.:|:.||||.||.||||||.||:.||.....:.:.::.:        |.|...|.|.|
Human   223 KVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQQDQQ--------NTQRLSSAQTN--- 276

  Fly   241 PMHLNGSKAGL------YPTHESSMDELSQDSSVH 269
                .|..||:      |....:....|:.:.||:
Human   277 ----GGGSAGMEGIMNPYTALPTPQQLLAIEQSVY 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	20/52 (38%)
		LIM2_AWH	69..123	CDD:188765	22/53 (42%)
		Homeodomain	149..205	CDD:459649	26/55 (47%)
LMX1A	NP_796372.1	LIM1_Lmx1a	35..86	CDD:188756	20/52 (38%)
		LIM2_Lmx1a_Lmx1b	94..148	CDD:188764	22/53 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..208		12/51 (24%)
		Homeodomain	196..252	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..285		9/47 (19%)