DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Awh and lhx5

DIOPT Version :9

Sequence 1:	NP_001261379.1	Gene:	Awh / 38451	FlyBaseID:	FBgn0013751	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_571293.1	Gene:	lhx5 / 30465	ZFINID:	ZDB-GENE-980526-484	Length:	399	Species:	Danio rerio

Alignment Length:	346	Identity:	114/346 - (32%)
Similarity:	159/346 - (45%)	Gaps:	90/346 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKADYSKNFGAKCSKC 72
            ||.|..||.|||.|.|...:|||.|::||.|.|.|  .:.||.|:.::|||.|:.:.||.||:.|
Zfish     5 CAGCERPILDRFLLNVLDRAWHAKCVQCCECNCNL--TEKCFSRDGKLYCKIDFFRRFGTKCAGC 67

  Fly    73 CRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDD-RVLCKAHYL------------ 124
            .:|||.||.|||||..||||.||.|..|.:||||||:..::|: :.:||..||
Zfish    68 LQGISPSDLVRRARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKEDYLSASAIKEVNLNS 132

  Fly   125 -------------------ETVE-GGTTSSDEGCDGDGYHK--SKTKR--VRTTFTEEQLQVLQA 165
                               :|.| ..:||||:..:.:...:  |.|||  .|||...:||:.|:|
Zfish   133 VSSCTDRSLSPDLPDQIQDDTKETDNSTSSDKDTNNNENEEQNSCTKRRGPRTTIKAKQLETLKA 197

  Fly   166 NFQIDSNPDGQDLERIASVTGLSKRVTQVWFQNSRARQKK---------HIHA---GKNKIR--- 215
            .|.....|.....|::|..|||:.||.||||||.|:::::         ..||   |..::|
Zfish   198 AFVATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRGPRRMRPLG 262

  Fly   216 ------------------EPEGSSFARHINLQLTYSF----------QNNAQNPMHL-NGSKA-- 249
                              |.:|..:...:|    |.|          .:.|::|..| :||.|
Zfish   263 GRLEDPDIMGPGGYSYYGEYQGDYYGPVVN----YDFFPHGPPSSQAHSPAESPYLLSSGSGALE 323

  Fly   250 -GLYPTHESSMDELSQDSSVH 269
             |....|..|.|:...|...|
Zfish   324 GGPVSAHHPSDDQRFTDMISH 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	25/52 (48%)
		LIM2_AWH	69..123	CDD:188765	29/54 (54%)
		Homeobox	152..204	CDD:278475	23/51 (45%)
lhx5	NP_571293.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	25/52 (48%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	29/54 (54%)
		COG5576	126..>242	CDD:227863	33/115 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..185		10/48 (21%)
		Homeobox	183..236	CDD:278475	23/52 (44%)
		GATA-N	298..>390	CDD:283099	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..399		12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910