DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Awh and Pitx1

DIOPT Version :9

Sequence 1:	NP_001261379.1	Gene:	Awh / 38451	FlyBaseID:	FBgn0013751	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_035227.1	Gene:	Pitx1 / 18740	MGIID:	107374	Length:	315	Species:	Mus musculus

Alignment Length:	81	Identity:	35/81 - (43%)
Similarity:	47/81 - (58%)	Gaps:	5/81 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 EGGTTSSDEGCDG---DGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDLERIASVTGLSK 189
            :||..|:  ||.|   |...|.|.:|.||.||.:|||.|:|.||.:..||....|.||..|.|::
Mouse    69 DGGAGSA--GCGGGAEDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTE 131

  Fly   190 RVTQVWFQNSRARQKK 205
            ...:|||:|.||:.:|
Mouse   132 PRVRVWFKNRRAKWRK 147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759
		LIM2_AWH	69..123	CDD:188765
		Homeobox	152..204	CDD:278475	24/51 (47%)
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		16/36 (44%)
		Homeobox	94..147	CDD:365835	24/52 (46%)
		Interaction with PIT-1	151..280
		Forkhead_N	196..>275	CDD:369872
		OAR	277..294	CDD:367680
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	281..294
		Nuclear localization signal. /evidence=ECO:0000255	287..291
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940