DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRAS and RAS1

DIOPT Version :9

Sequence 1:	NP_001356715.1	Gene:	KRAS / 3845	HGNCID:	6407	Length:	189	Species:	Homo sapiens
Sequence 2:	NP_014744.1	Gene:	RAS1 / 854268	SGDID:	S000005627	Length:	309	Species:	Saccharomyces cerevisiae

Alignment Length:	163	Identity:	103/163 - (63%)
Similarity:	131/163 - (80%)	Gaps:	1/163 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     3 EYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAM 67
            |||:||||.|||||||||||.||::||||||||||||||||||||.:..:|||||||||||||||
Yeast    10 EYKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAM 74

Human    68 RDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPS-RTVDTKQAQ 131
            |:||||||||||.|:::.:..||:::..|.:||:|||||:.:|:|:||||.||.: |.|..:...
Yeast    75 REQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGL 139

Human   132 DLARSYGIPFIETSAKTRQRVEDAFYTLVREIR 164
            .||:....||:|||||....|::|||:|:|.:|
Yeast   140 RLAKQLNAPFLETSAKQAINVDEAFYSLIRLVR 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRAS	NP_001356715.1	H_N_K_Ras_like	3..164	CDD:133338	102/161 (63%)
		Effector region	32..40		7/7 (100%)
		Hypervariable region	166..185
RAS1	NP_014744.1	small_GTPase	9..172	CDD:197466	102/161 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100217
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1068
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.700