DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRAS and Rala

DIOPT Version :9

Sequence 1:	NP_001356715.1	Gene:	KRAS / 3845	HGNCID:	6407	Length:	189	Species:	Homo sapiens
Sequence 2:	NP_525063.1	Gene:	Rala / 31332	FlyBaseID:	FBgn0015286	Length:	201	Species:	Drosophila melanogaster

Alignment Length:	193	Identity:	97/193 - (50%)
Similarity:	138/193 - (71%)	Gaps:	10/193 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     4 YKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMR 68
            :|:::||:|||||||||:|.:.:.||::|:||..|||||:||:|||...:|||||||||:|:|:|
  Fly    12 HKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIR 76

Human    69 DQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL-PSRTVDTKQAQD 132
            |.|.|:||||||||:|.:.:||:....:||||.|||:.|.:|.:|||||||| ..|.|...:.|.
  Fly    77 DNYFRSGEGFLCVFSITDDESFQATQEFREQILRVKNDESIPFLLVGNKCDLNDKRKVPLSECQL 141

Human   133 LARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPG-----CVKIK-KCIIM 189
            .|:.:.:|::|||||||:.|:..|:.|:||||.   :|....:.|.|     |.|.: ||.::
  Fly   142 RAQQWAVPYVETSAKTRENVDKVFFDLMREIRS---RKTEDSKATSGRAKDRCKKRRLKCTLL 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRAS	NP_001356715.1	H_N_K_Ras_like	3..164	CDD:133338	88/160 (55%)
		Effector region	32..40		4/7 (57%)
		Hypervariable region	166..185		5/24 (21%)
Rala	NP_525063.1	RalA_RalB	12..174	CDD:206710	89/161 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820