DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRAS and ras1

DIOPT Version :9

Sequence 1:	NP_001356715.1	Gene:	KRAS / 3845	HGNCID:	6407	Length:	189	Species:	Homo sapiens
Sequence 2:	NP_593579.1	Gene:	ras1 / 2542285	PomBaseID:	SPAC17H9.09c	Length:	219	Species:	Schizosaccharomyces pombe

Alignment Length:	177	Identity:	113/177 - (63%)
Similarity:	135/177 - (76%)	Gaps:	5/177 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65
            :.||||||||.||||||||||||||:||||||||||||||||:..||||..|||:||||||||||
pombe     6 LREYKLVVVGDGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKKCEIDGEGALLDVLDTAGQEEYS 70

Human    66 AMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPS-RTVDTKQ 129
            |||:||||||||||.|:.|.:..||::|..:.:||.||||.:..|:|||.|||||.: |.|...:
pombe    71 AMREQYMRTGEGFLLVYNITSRSSFDEISTFYQQILRVKDKDTFPVVLVANKCDLEAERVVSRAE 135

Human   130 AQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEK 176
            .:.||:|....::|||||.|..||:|||:|||.||:|.    ..|||
pombe   136 GEQLAKSMHCLYVETSAKLRLNVEEAFYSLVRTIRRYN----KSEEK 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRAS	NP_001356715.1	H_N_K_Ras_like	3..164	CDD:133338	107/161 (66%)
		Effector region	32..40		7/7 (100%)
		Hypervariable region	166..185		4/11 (36%)
ras1	NP_593579.1	small_GTPase	7..172	CDD:197466	109/164 (66%)
ras1	NP_593579.1	H_N_K_Ras_like	8..170	CDD:133338	107/161 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100217
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1068
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.700