Protein Alignment KRAS and let-60

DIOPT Version :9

• Sequence 1: NP_001356715.1
• Gene: KRAS / 3845
• HGNCID: 6407
• Length: 189
• Species: Homo sapiens
• Sequence 2: NP_502213.3
• Gene: let-60 / 178104
• WormBaseID: WBGene00002335
• Length: 184
• Species: Caenorhabditis elegans
• Alignment Length: 189
• Identity: 141/189 - (74%)
• Similarity: 162/189 - (85%)
• Gaps: 5/189 - (2%)

Human     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65
            ||||||||||.||||||||||||||||||:|||||||||||||||||||||||||||||||||||
 Worm     1 MTEYKLVVVGDGGVGKSALTIQLIQNHFVEEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65

Human    66 AMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQA 130
            ||||||||||||||.|||:|..||||::.:|||||:|||||:|||||||||||||.||:||.:..
 Worm    66 AMRDQYMRTGEGFLLVFAVNEAKSFENVANYREQIRRVKDSDDVPMVLVGNKCDLSSRSVDFRTV 130

Human   131 QDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 189
            .:.|:.||||.::||||||..|::||||||||||::|.:..:.:.:     |.|||.||
 Worm   131 SETAKGYGIPNVDTSAKTRMGVDEAFYTLVREIRKHRERHDNNKPQ-----KKKKCQIM 184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRAS	NP_001356715.1	H_N_K_Ras_like	3..164	CDD:133338	130/160 (81%)
		Effector region	32..40		7/7 (100%)
		Hypervariable region	166..185		2/18 (11%)
let-60	NP_502213.3	H_N_K_Ras_like	3..164	CDD:133338	130/160 (81%)
		small_GTPase	16..166	CDD:197466	120/149 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1094
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37990
Inparanoid	1	1.050	284	1.000	Inparanoid score	I1975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	1	1.000	-	-		otm15429
orthoMCL	1	0.900	-	-		OOG6_100217
Panther	1	1.100	-	-	O	PTHR24070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1068
SonicParanoid	1	1.000	-	-		X934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.900