DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRAS and Kras

DIOPT Version :9

Sequence 1:	NP_001356715.1	Gene:	KRAS / 3845	HGNCID:	6407	Length:	189	Species:	Homo sapiens
Sequence 2:	XP_006506982.1	Gene:	Kras / 16653	MGIID:	96680	Length:	227	Species:	Mus musculus

Alignment Length:	189	Identity:	187/189 - (98%)
Similarity:	189/189 - (100%)	Gaps:	0/189 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYS 65

Human    66 AMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 AMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQA 130

Human   131 QDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 189
            |:||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
Mouse   131 QELARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCVIM 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRAS	NP_001356715.1	H_N_K_Ras_like	3..164	CDD:133338	159/160 (99%)
		Effector region	32..40		7/7 (100%)
		Hypervariable region	166..185		18/18 (100%)
Kras	XP_006506982.1	H_N_K_Ras_like	3..164	CDD:133338	159/160 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83953418
Domainoid	1	1.000	320	1.000	Domainoid score	I15087
eggNOG	1	0.900	-	-		E2759_KOG0395
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37990
Inparanoid	1	1.050	379	1.000	Inparanoid score	I13985
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1259506at2759
OrthoFinder	1	1.000	-	-		FOG0000092
OrthoInspector	1	1.000	-	-		oto127270
orthoMCL	1	0.900	-	-		OOG6_100217
Panther	1	1.100	-	-	LDO	PTHR24070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1068
SonicParanoid	1	1.000	-	-		X934
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.290