DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scsalpha1 and SUCLG1

DIOPT Version :9

Sequence 1:	NP_001189044.1	Gene:	Scsalpha1 / 38447	FlyBaseID:	FBgn0004888	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_003840.2	Gene:	SUCLG1 / 8802	HGNCID:	11449	Length:	346	Species:	Homo sapiens

Alignment Length:	340	Identity:	222/340 - (65%)
Similarity:	277/340 - (81%)	Gaps:	14/340 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AASMRALLKVRDGFVA-------------GVRCNSQYNKTRGNLKLNGDSRVICQGFTGKQGTFH 53
            ||.:..::....|..|             |:| :..|..:|.:|.::.::::|||||||||||||
Human     8 AADIATMVSGSSGLAAARLLSRSFLLPQNGIR-HCSYTASRQHLYVDKNTKIICQGFTGKQGTFH 71

  Fly    54 SQQALEYGTKLVGGISPKKGGTQHLGLPVFASVAEAKKATDPHATVIYVPPPGAAAAIIEALEAE 118
            ||||||||||||||.:|.|||..|||||||.:|.|||:.|...|:|||||||.|||||.||:|||
Human    72 SQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAIEAE 136

  Fly   119 IPLIVCITEGVPQHDMVKVKHALISQSKSRLVGPNCPGIIAPEQCKIGIMPGHIHKRGKIGVVSR 183
            |||:||||||:||.|||:|||.|:.|.|:||:||||||:|.|.:||||||||||||:|:||:|||
Human   137 IPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSR 201

  Fly   184 SGTLTYEAVHQTTEVGLGQTLCVGIGGDPFNGTDFIDCLEVFLKDPETKGIILIGEIGGVAEEKA 248
            |||||||||||||:|||||:||||||||||||||||||||:||.|..|:||||||||||.|||.|
Human   202 SGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENA 266

  Fly   249 ADYLTEYNSGIKAKPVVSFIAGVSAPPGRRMGHAGAIISGGKGGANDKIAALEKAGVIVTRSPAK 313
            |::|.::|||..:|||||||||::||||||||||||||:||||||.:||:||:.|||:|:.|||:
Human   267 AEFLKQHNSGPNSKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQ 331

  Fly   314 MGHELFKEMKRLELV 328
            :|..::||.::.:::
Human   332 LGTTIYKEFEKRKML 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scsalpha1	NP_001189044.1	PTZ00187	22..325	CDD:240307	216/302 (72%)
SUCLG1	NP_003840.2	Ligase_CoA	199..324	CDD:304578	99/124 (80%)
		PTZ00187	19..344	CDD:240307	220/325 (68%)
		CoA_binding	53..146	CDD:280747	68/92 (74%)
		Coenzyme A binding. /evidence=ECO:0000255\|HAMAP-Rule:MF_03222	64..67		2/2 (100%)
		Coenzyme A binding. /evidence=ECO:0000255\|HAMAP-Rule:MF_03222	143..145		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152712
Domainoid	1	1.000	209	1.000	Domainoid score	I2850
eggNOG	1	0.900	-	-		E1_COG0074
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55785
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1574
Isobase	1	0.950	-	0	Normalized mean entropy	S294
OMA	1	1.010	-	-		QHG60703
OrthoDB	1	1.010	-	-		D1247548at2759
OrthoFinder	1	1.000	-	-		FOG0002539
OrthoInspector	1	1.000	-	-		otm41884
orthoMCL	1	0.900	-	-		OOG6_100834
Panther	1	1.100	-	-	LDO	PTHR11117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1411
SonicParanoid	1	1.000	-	-		X1662
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750