DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scsalpha1 and LSC1

DIOPT Version :9

Sequence 1:	NP_001189044.1	Gene:	Scsalpha1 / 38447	FlyBaseID:	FBgn0004888	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_014785.3	Gene:	LSC1 / 854310	SGDID:	S000005668	Length:	329	Species:	Saccharomyces cerevisiae

Alignment Length:	306	Identity:	176/306 - (57%)
Similarity:	216/306 - (70%)	Gaps:	4/306 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YNKTRGNLKLNGDSRVICQGFTGKQGTFHSQQALEYGTKLVGGISPKKGGTQHLGLPVFASVAEA 89
            |:||..||.|..|::||.|||||||||||:..:.||||.:|||.:|||.|..|||.||||||.:|
Yeast    24 YDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDA 88

  Fly    90 KKATDPHATVIYVPPPGAAAAIIEALEAEIPLIVCITEGVPQHDMVKVKHALISQSKSRLVGPNC 154
            .|.|...|:.|:||||.|||||.|::||||||.||||||:|||||:.:...|.:|.|:|||||||
Yeast    89 IKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNC 153

  Fly   155 PGIIAP-EQCKIGIMPGHIHKRGKIGVVSRSGTLTYEAVHQTTEVGLGQTLCVGIGGDPFNGTDF 218
            ||||.| .:.:|||.|..|.:.||||::|||||||||||.|||:..|||:|.:|:|||.|.||||
Yeast   154 PGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDF 218

  Fly   219 IDCLEVFLKDPETKGIILIGEIGGVAEEKAADYLTEYN-SGIKAKPVVSFIAGVSA--PPGRRMG 280
            ||.|::||:|..|:|||::|||||.||.:||.:|.||| |..|..||.|||||..|  ..|.|||
Yeast   219 IDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMG 283

  Fly   281 HAGAIISGGKGGANDKIAALEKAGVIVTRSPAKMGHELFKEMKRLE 326
            |:|||:.|....|..|..||...||.|..||..:|..|..:..:.:
Yeast   284 HSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scsalpha1	NP_001189044.1	PTZ00187	22..325	CDD:240307	176/303 (58%)
LSC1	NP_014785.3	PTZ00187	24..327	CDD:240307	176/302 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344858
Domainoid	1	1.000	137	1.000	Domainoid score	I1063
eggNOG	1	0.900	-	-		E1_COG0074
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55785
Inparanoid	1	1.050	330	1.000	Inparanoid score	I426
Isobase	1	0.950	-	0	Normalized mean entropy	S294
OMA	1	1.010	-	-		QHG60703
OrthoFinder	1	1.000	-	-		FOG0002539
OrthoInspector	1	1.000	-	-		otm46914
orthoMCL	1	0.900	-	-		OOG6_100834
Panther	1	1.100	-	-	LDO	PTHR11117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1411
SonicParanoid	1	1.000	-	-		X1662
TreeFam	1	0.960	-	-
	16	15.740