DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scsalpha1 and sucl-2

DIOPT Version :9

Sequence 1:	NP_001189044.1	Gene:	Scsalpha1 / 38447	FlyBaseID:	FBgn0004888	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_497288.1	Gene:	sucl-2 / 175252	WormBaseID:	WBGene00017759	Length:	321	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	223/322 - (69%)
Similarity:	256/322 - (79%)	Gaps:	7/322 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAASMRALLKVRDGFVAGVRCNSQYNKTRGNLKLNGDSRVICQGFTGKQGTFHSQQALEYGTKLV 65
            :|::.||..:      |.| ..|.||.||.||.:|..::||.|||||:||||||:|.|||.|.||
Worm     5 LASAARAATR------AAV-TRSVYNDTRNNLMINKSTKVIVQGFTGRQGTFHSKQMLEYNTNLV 62

  Fly    66 GGISPKKGGTQHLGLPVFASVAEAKKATDPHATVIYVPPPGAAAAIIEALEAEIPLIVCITEGVP 130
            ||:||.|.|..|||||||.||||||..|...|||||||..|||.||.||::|||.|||.||||:|
Worm    63 GGVSPNKAGQTHLGLPVFGSVAEAKDRTGADATVIYVPAAGAARAIHEAMDAEIGLIVAITEGIP 127

  Fly   131 QHDMVKVKHALISQSKSRLVGPNCPGIIAPEQCKIGIMPGHIHKRGKIGVVSRSGTLTYEAVHQT 195
            |.|||:||:.|:.|:||||:|||||||||...||||||||||||:|.||:|||||||||||||||
Worm   128 QQDMVRVKNRLLKQNKSRLLGPNCPGIIASGDCKIGIMPGHIHKKGCIGIVSRSGTLTYEAVHQT 192

  Fly   196 TEVGLGQTLCVGIGGDPFNGTDFIDCLEVFLKDPETKGIILIGEIGGVAEEKAADYLTEYNSGIK 260
            |.||||||.|:||||||||||:|||||||||:|.:||||||||||||.|||:||::|...|||..
Worm   193 TTVGLGQTRCIGIGGDPFNGTNFIDCLEVFLEDEQTKGIILIGEIGGQAEEQAAEFLKSRNSGSN 257

  Fly   261 AKPVVSFIAGVSAPPGRRMGHAGAIISGGKGGANDKIAALEKAGVIVTRSPAKMGHELFKEM 322
            |||||||||||:||||||||||||||:||||.|.|||.||..|.|:||.||||:|..:.|.:
Worm   258 AKPVVSFIAGVTAPPGRRMGHAGAIIAGGKGTAGDKIEALRNANVVVTDSPAKLGVAMQKAL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scsalpha1	NP_001189044.1	PTZ00187	22..325	CDD:240307	218/301 (72%)
sucl-2	NP_497288.1	PTZ00187	19..319	CDD:240307	218/299 (73%)
		CoA_binding	32..125	CDD:280747	63/92 (68%)
		Ligase_CoA	178..303	CDD:304578	100/124 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162587
Domainoid	1	1.000	213	1.000	Domainoid score	I1596
eggNOG	1	0.900	-	-		E1_COG0074
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55785
Inparanoid	1	1.050	451	1.000	Inparanoid score	I901
Isobase	1	0.950	-	0	Normalized mean entropy	S294
OMA	1	1.010	-	-		QHG60703
OrthoDB	1	1.010	-	-		D1247548at2759
OrthoFinder	1	1.000	-	-		FOG0002539
OrthoInspector	1	1.000	-	-		otm14814
orthoMCL	1	0.900	-	-		OOG6_100834
Panther	1	1.100	-	-	O	PTHR11117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1411
SonicParanoid	1	1.000	-	-		X1662
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790