DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-B and PIGB

DIOPT Version :9

Sequence 1:	NP_647832.1	Gene:	PIG-B / 38446	FlyBaseID:	FBgn0035464	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_004846.4	Gene:	PIGB / 9488	HGNCID:	8959	Length:	554	Species:	Homo sapiens

Alignment Length:	539	Identity:	213/539 - (39%)
Similarity:	297/539 - (55%)	Gaps:	66/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIAGLY 68
            ||:.|..:|:|:.:.|:|||.:|||||||||||:|.:.|.||||||||.:.:|||.|||:.|.:|
Human    61 IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLIFASIY 125

  Fly    69 KILALLQLDSAHLLVVLPRIVQALLSAYSDYRFFVWTGK------RKWALFLILVPWFWFYTGSR 127
            |||.||..||..||:.:||:.||||||.:|.|.:....:      .:|..|..|..||.:|..:|
Human   126 KILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTR 190

  Fly   128 TLANTLEASLTTIALSYFPWYG----ESTAYLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVL 188
            ||.||:|..||.|||.|:|..|    .|..|....|:...:||||.::|.||...|..:..:. |
Human   191 TLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-L 254

  Fly   189 ELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTV 253
            :|||..|:.:|.:...|.:.||..:.||..:..:.|||:|:..|.|:||||||||||||.|.|.:
Human   255 DLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVI 319

  Fly   254 LGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCL----YVI 314
            ||.:...||.|.....|   :|.:   ||:|:..||:|.|.:.||||||:.|:||.|:    |.:
Human   320 LGTHLPFFIHGCYLAPK---RYRI---LLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 378

  Fly   315 TDALSRWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQAN 379
            |. |..|...|.|        .:.:.|:..|.|...|||:|.:::|..::::.  |.:..:..|:
Human   379 TH-LKTWKKPALS--------FLFLSNLFLALYTGLVHQRGTLDVMSHIQKVC--YNNPNKSSAS 432

  Fly   380 ILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHPLTALP 444
            |..:|||||||||||:|..:.||||.|.|:|..|..|.||||.|:.:|::|:  |...|...:||
Human   433 IFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGKSHYLDEADVFYLNPLNWL--HREFHDDASLP 495

  Fly   445 THVVLFDPLAENISVFL--RNYRLLHRIEHAEVTRLEGSQALVDQWSEALGAQSPNLASLLQNRQ 507
            ||::.|..|.|.||.||  .||:......|..:.                              :
Human   496 THLITFSILEEEISAFLISSNYKRTAVFFHTHLP------------------------------E 530

  Fly   508 SRTGRSILVYQRLKKGEEN 526
            .|.|..|.||:|..||:.|
Human   531 GRIGSHIYVYERKLKGKFN 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-B	NP_647832.1	Glyco_transf_22	5..396	CDD:281842	170/404 (42%)
PIGB	NP_004846.4	Glyco_transf_22	62..449	CDD:281842	170/404 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156580
Domainoid	1	1.000	323	1.000	Domainoid score	I1218
eggNOG	1	0.900	-	-		E1_KOG1771
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3570
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2066
Isobase	1	0.950	-	0	Normalized mean entropy	S2561
OMA	1	1.010	-	-		QHG54776
OrthoDB	1	1.010	-	-		D281304at33208
OrthoFinder	1	1.000	-	-		FOG0005162
OrthoInspector	1	1.000	-	-		oto89689
orthoMCL	1	0.900	-	-		OOG6_103087
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R510
SonicParanoid	1	1.000	-	-		X3680
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750